Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis
Environmental noise is a common hazard in military operations. Military service members during long operations are often exposed to around-the-clock noise and suffer massive emotional and cognitive dysfunction related to an Alzheimer’s disease (AD)-like neuropathology. It is essential to clarify the...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/17/2742 |
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| author | Pengfang Zheng Xiaojun She Chunping Wang Yingwen Zhu Bo Fu Kefeng Ma Honglian Yang Xiujie Gao Xiaofang Li Fangshan Wu Bo Cui |
| author_facet | Pengfang Zheng Xiaojun She Chunping Wang Yingwen Zhu Bo Fu Kefeng Ma Honglian Yang Xiujie Gao Xiaofang Li Fangshan Wu Bo Cui |
| author_sort | Pengfang Zheng |
| collection | DOAJ |
| description | Environmental noise is a common hazard in military operations. Military service members during long operations are often exposed to around-the-clock noise and suffer massive emotional and cognitive dysfunction related to an Alzheimer’s disease (AD)-like neuropathology. It is essential to clarify the mechanisms underlying the effects of around-the-clock noise exposure on the central nervous system. Here, Wistar rats were continuously exposed to white noise (95 dB during the on-duty phase [8:00–16:00] and 75 dB during the off-duty phase (16:00–8:00 the next day)) for 40 days. The levels of phosphorylated tau, amyloid-β (Aβ), and neuroinflammation in the cortex and hippocampus were assessed and autophagosome (AP) aggregation was observed by transmission electron microscopy. Dyshomeostasis of autophagic flux resulting from around-the-clock noise exposure was assessed at different stages to investigate the potential pathological mechanisms. Around-the-clock noise significantly increased Aβ peptide, tau phosphorylation at Ser396 and Ser404, and neuroinflammation. Moreover, the AMPK-mTOR signaling pathway was depressed in the cortex and the hippocampus of rats exposed to around-the-clock noise. Consequently, autophagosome–lysosome fusion was deterred and resulted in AP accumulation. Our results indicate that around-the-clock noise exposure has detrimental influences on autophagic flux homeostasis and may be associated with AD-like neuropathology in the cortex and the hippocampus. |
| first_indexed | 2024-03-10T01:56:03Z |
| format | Article |
| id | doaj.art-7a50f682514e41c1901f66f2efb1f545 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:56:03Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7a50f682514e41c1901f66f2efb1f5452023-11-23T12:56:12ZengMDPI AGCells2073-44092022-09-011117274210.3390/cells11172742Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux HomeostasisPengfang Zheng0Xiaojun She1Chunping Wang2Yingwen Zhu3Bo Fu4Kefeng Ma5Honglian Yang6Xiujie Gao7Xiaofang Li8Fangshan Wu9Bo Cui10School of Public Health, Weifang Medical University, No. 7166, Baotong Xi Street, Weicheng District, Weifang 261053, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaSchool of Public Health, Weifang Medical University, No. 7166, Baotong Xi Street, Weicheng District, Weifang 261053, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaTianjin Institute of Environmental and Operational Medicine, No. 1, Dali Road, Heping District, Tianjin 300050, ChinaSchool of Public Health, Weifang Medical University, No. 7166, Baotong Xi Street, Weicheng District, Weifang 261053, ChinaSchool of Public Health, Weifang Medical University, No. 7166, Baotong Xi Street, Weicheng District, Weifang 261053, ChinaEnvironmental noise is a common hazard in military operations. Military service members during long operations are often exposed to around-the-clock noise and suffer massive emotional and cognitive dysfunction related to an Alzheimer’s disease (AD)-like neuropathology. It is essential to clarify the mechanisms underlying the effects of around-the-clock noise exposure on the central nervous system. Here, Wistar rats were continuously exposed to white noise (95 dB during the on-duty phase [8:00–16:00] and 75 dB during the off-duty phase (16:00–8:00 the next day)) for 40 days. The levels of phosphorylated tau, amyloid-β (Aβ), and neuroinflammation in the cortex and hippocampus were assessed and autophagosome (AP) aggregation was observed by transmission electron microscopy. Dyshomeostasis of autophagic flux resulting from around-the-clock noise exposure was assessed at different stages to investigate the potential pathological mechanisms. Around-the-clock noise significantly increased Aβ peptide, tau phosphorylation at Ser396 and Ser404, and neuroinflammation. Moreover, the AMPK-mTOR signaling pathway was depressed in the cortex and the hippocampus of rats exposed to around-the-clock noise. Consequently, autophagosome–lysosome fusion was deterred and resulted in AP accumulation. Our results indicate that around-the-clock noise exposure has detrimental influences on autophagic flux homeostasis and may be associated with AD-like neuropathology in the cortex and the hippocampus.https://www.mdpi.com/2073-4409/11/17/2742around-the-clock noiseAMPK-mTORautophagosomelysosomeAlzheimer’s disease |
| spellingShingle | Pengfang Zheng Xiaojun She Chunping Wang Yingwen Zhu Bo Fu Kefeng Ma Honglian Yang Xiujie Gao Xiaofang Li Fangshan Wu Bo Cui Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis Cells around-the-clock noise AMPK-mTOR autophagosome lysosome Alzheimer’s disease |
| title | Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis |
| title_full | Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis |
| title_fullStr | Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis |
| title_full_unstemmed | Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis |
| title_short | Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis |
| title_sort | around the clock noise induces ad like neuropathology by disrupting autophagy flux homeostasis |
| topic | around-the-clock noise AMPK-mTOR autophagosome lysosome Alzheimer’s disease |
| url | https://www.mdpi.com/2073-4409/11/17/2742 |
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