Ferrocene-Based Compounds with Antimalaria/Anticancer Activity
Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/19/3604 |
| _version_ | 1819172940618399744 |
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| author | Sijongesonke Peter Blessing Atim Aderibigbe |
| author_facet | Sijongesonke Peter Blessing Atim Aderibigbe |
| author_sort | Sijongesonke Peter |
| collection | DOAJ |
| description | Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity. |
| first_indexed | 2024-12-22T20:15:10Z |
| format | Article |
| id | doaj.art-7a5420313db44be694dad8cdc17ed6a3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T20:15:10Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7a5420313db44be694dad8cdc17ed6a32022-12-21T18:13:58ZengMDPI AGMolecules1420-30492019-10-012419360410.3390/molecules24193604molecules24193604Ferrocene-Based Compounds with Antimalaria/Anticancer ActivitySijongesonke Peter0Blessing Atim Aderibigbe1Department of Chemistry, University of Fort Hare, Alice campus, Eastern Cape 5700, South AfricaDepartment of Chemistry, University of Fort Hare, Alice campus, Eastern Cape 5700, South AfricaMalaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity.https://www.mdpi.com/1420-3049/24/19/3604organometallicsmalariacancerferrocene compoundsferroquine |
| spellingShingle | Sijongesonke Peter Blessing Atim Aderibigbe Ferrocene-Based Compounds with Antimalaria/Anticancer Activity Molecules organometallics malaria cancer ferrocene compounds ferroquine |
| title | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity |
| title_full | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity |
| title_fullStr | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity |
| title_full_unstemmed | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity |
| title_short | Ferrocene-Based Compounds with Antimalaria/Anticancer Activity |
| title_sort | ferrocene based compounds with antimalaria anticancer activity |
| topic | organometallics malaria cancer ferrocene compounds ferroquine |
| url | https://www.mdpi.com/1420-3049/24/19/3604 |
| work_keys_str_mv | AT sijongesonkepeter ferrocenebasedcompoundswithantimalariaanticanceractivity AT blessingatimaderibigbe ferrocenebasedcompoundswithantimalariaanticanceractivity |