MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322002388 |
| _version_ | 1811178135709810688 |
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| author | Luis Alberto Bravo-Vázquez Natalia Frías-Reid Ana Gabriela Ramos-Delgado Sofía Madeline Osorio-Pérez Hania Ruth Zlotnik-Chávez Surajit Pathak Antara Banerjee Anindya Bandyopadhyay Asim K. Duttaroy Sujay Paul |
| author_facet | Luis Alberto Bravo-Vázquez Natalia Frías-Reid Ana Gabriela Ramos-Delgado Sofía Madeline Osorio-Pérez Hania Ruth Zlotnik-Chávez Surajit Pathak Antara Banerjee Anindya Bandyopadhyay Asim K. Duttaroy Sujay Paul |
| author_sort | Luis Alberto Bravo-Vázquez |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance, apoptosis, autophagy, cell differentiation, tumor suppression, tumor growth, cancer cell proliferation, migration, and invasion in PC. Moreover, several aberrantly expressed miRNAs and lncRNAs have the potential to be used as biomarkers for accurate PC diagnosis. Additionally, miRNAs and lncRNAs are considered as promising clinical targets for PC. Therefore, in this review, we discuss recent experimental evidence regarding the clinical implications of miRNAs and lncRNAs in the pathophysiology of PC, their future potential, as well as the challenges that have arisen in this field of study in order to drive forward the design of ncRNA-based diagnostics and therapeutics for PC. |
| first_indexed | 2024-04-11T06:13:01Z |
| format | Article |
| id | doaj.art-7a55fd646a204880af1972b77d70dd3c |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-04-11T06:13:01Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-7a55fd646a204880af1972b77d70dd3c2022-12-22T04:41:08ZengElsevierTranslational Oncology1936-52332023-01-0127101579MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applicationsLuis Alberto Bravo-Vázquez0Natalia Frías-Reid1Ana Gabriela Ramos-Delgado2Sofía Madeline Osorio-Pérez3Hania Ruth Zlotnik-Chávez4Surajit Pathak5Antara Banerjee6Anindya Bandyopadhyay7Asim K. Duttaroy8Sujay Paul9School of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, MexicoDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaDepartment of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai, IndiaInternational Rice Research Institute, Manila 4031, Philippines; Reliance Industries Ltd., Navi Mumbai 400701, IndiaDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, POB 1046, Blindern, Oslo, Norway; Corresponding authors.School of Engineering and Sciences, Tecnologico de Monterrey, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico; Corresponding authors.MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance, apoptosis, autophagy, cell differentiation, tumor suppression, tumor growth, cancer cell proliferation, migration, and invasion in PC. Moreover, several aberrantly expressed miRNAs and lncRNAs have the potential to be used as biomarkers for accurate PC diagnosis. Additionally, miRNAs and lncRNAs are considered as promising clinical targets for PC. Therefore, in this review, we discuss recent experimental evidence regarding the clinical implications of miRNAs and lncRNAs in the pathophysiology of PC, their future potential, as well as the challenges that have arisen in this field of study in order to drive forward the design of ncRNA-based diagnostics and therapeutics for PC.http://www.sciencedirect.com/science/article/pii/S1936523322002388Pancreatic cancerMicroRNAslncRNAsBiomarkerTherapeutics |
| spellingShingle | Luis Alberto Bravo-Vázquez Natalia Frías-Reid Ana Gabriela Ramos-Delgado Sofía Madeline Osorio-Pérez Hania Ruth Zlotnik-Chávez Surajit Pathak Antara Banerjee Anindya Bandyopadhyay Asim K. Duttaroy Sujay Paul MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications Translational Oncology Pancreatic cancer MicroRNAs lncRNAs Biomarker Therapeutics |
| title | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_full | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_fullStr | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_full_unstemmed | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_short | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_sort | micrornas and long non coding rnas in pancreatic cancer from epigenetics to potential clinical applications |
| topic | Pancreatic cancer MicroRNAs lncRNAs Biomarker Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322002388 |
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