Squamous neoplasia of the ocular surface in patients with pterygium in Peru
Objectives. To estimate the frequency of unsuspected ocular surface squamous neoplasia (OSSN) in pterygium, the accuracy of clinical diagnosis, and associated demographic and clinical characteristics. Materials and methods. We reviewed histopathological reports of patients with a clinical diagnosis...
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| Format: | Article |
| Language: | Spanish |
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Instituto Nacional de Salud
2014-12-01
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| Series: | Revista Peruana de Medicina Experimental y Salud Pública |
| Subjects: | |
| Online Access: | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/119 |
| _version_ | 1828855215478013952 |
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| author | Luis Furuya-Kanamori Carlos M. Dulanto-Reinoso Jennifer C Stone Leila Marroquín Victor Ch. Dulanto-Reinoso José A. Roca Francisco Contreras Graham A. Lee |
| author_facet | Luis Furuya-Kanamori Carlos M. Dulanto-Reinoso Jennifer C Stone Leila Marroquín Victor Ch. Dulanto-Reinoso José A. Roca Francisco Contreras Graham A. Lee |
| author_sort | Luis Furuya-Kanamori |
| collection | DOAJ |
| description | Objectives. To estimate the frequency of unsuspected ocular surface squamous neoplasia (OSSN) in pterygium, the accuracy of clinical diagnosis, and associated demographic and clinical characteristics. Materials and methods. We reviewed histopathological reports of patients with a clinical diagnosis of pterygium and/or OSSN who were surgically treated between March 2009 and December 2012 at the National Eye Institute in Lima, Peru. The accuracy of the clinical diagnosis of OSSN was assessed by sensitivity, specificity, and likelihood ratios. Models of negative log-log regression were performed to identify demographic and clinical characteristics associated with increased odds of diagnosing OSSN. Results. 3,021 histopathological reports were reviewed. The frequency of unsuspected OSSN in pterygium was 0.65%. Clinical diagnosis had a sensitivity of 85%, a specificity of 99%, a positive likelihood ratio of 111.89, and a negative likelihood ratio of 0.15. Associated characteristics were male gender (OR =1.15; 95% CI: 1.01 to 1.30), age group of 61- 80 years (OR = 1.54, 95% CI: 1.28 to 1.85) ≥ 81 years (OR = 3.10; 95% CI: 2.09 to 4.58), presence of recurrent lesions (OR = 1.59; 95% CI: 1.03 to 2.46) and temporal location lesions (OR = 3.57; 95% CI: 2.63 to 4.85). These characteristics were associated with a greater likelihood of OSSN. Conclusions. A low frequency of unsuspected OSSN was found; however, it is recommended to routinely perform histopathology studies to avoid misdiagnosis of OSSN as pterygium. |
| first_indexed | 2024-12-13T00:50:31Z |
| format | Article |
| id | doaj.art-7a5755b0b4b1406c8d41fae088d7dff3 |
| institution | Directory Open Access Journal |
| issn | 1726-4634 1726-4642 |
| language | Spanish |
| last_indexed | 2024-12-13T00:50:31Z |
| publishDate | 2014-12-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Revista Peruana de Medicina Experimental y Salud Pública |
| spelling | doaj.art-7a5755b0b4b1406c8d41fae088d7dff32022-12-22T00:04:56ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422014-12-0131410.17843/rpmesp.2014.314.119119Squamous neoplasia of the ocular surface in patients with pterygium in PeruLuis Furuya-Kanamori0Carlos M. Dulanto-Reinoso1Jennifer C Stone2Leila Marroquín3Victor Ch. Dulanto-Reinoso4José A. Roca5Francisco Contreras6Graham A. Lee7The University of Queensland. Brisbane, Australia.Instituto Nacional de Oftalmología. Lima, Perú Universidad Peruana Cayetano Heredia. Lima, Perú.The University of Queensland. Brisbane, Australia.Instituto Nacional de Oftalmología. Lima, Perú´.Universidad de de Sao Paulo. Sao Paulo, Brasil.Servicio de Oftalmología, Clínica Ricardo Palma. Lima, Perú.Universidad Peruana Cayetano Heredia. Lima, Perú Servicio de Oftalmología, Clínica Ricardo Palma. Lima, Perú.The University of Queensland. Brisbane, Australia City Eye Centre. Brisbane, Australia Royal Brisbane & Womens Hospital. Herston, Australia.Objectives. To estimate the frequency of unsuspected ocular surface squamous neoplasia (OSSN) in pterygium, the accuracy of clinical diagnosis, and associated demographic and clinical characteristics. Materials and methods. We reviewed histopathological reports of patients with a clinical diagnosis of pterygium and/or OSSN who were surgically treated between March 2009 and December 2012 at the National Eye Institute in Lima, Peru. The accuracy of the clinical diagnosis of OSSN was assessed by sensitivity, specificity, and likelihood ratios. Models of negative log-log regression were performed to identify demographic and clinical characteristics associated with increased odds of diagnosing OSSN. Results. 3,021 histopathological reports were reviewed. The frequency of unsuspected OSSN in pterygium was 0.65%. Clinical diagnosis had a sensitivity of 85%, a specificity of 99%, a positive likelihood ratio of 111.89, and a negative likelihood ratio of 0.15. Associated characteristics were male gender (OR =1.15; 95% CI: 1.01 to 1.30), age group of 61- 80 years (OR = 1.54, 95% CI: 1.28 to 1.85) ≥ 81 years (OR = 3.10; 95% CI: 2.09 to 4.58), presence of recurrent lesions (OR = 1.59; 95% CI: 1.03 to 2.46) and temporal location lesions (OR = 3.57; 95% CI: 2.63 to 4.85). These characteristics were associated with a greater likelihood of OSSN. Conclusions. A low frequency of unsuspected OSSN was found; however, it is recommended to routinely perform histopathology studies to avoid misdiagnosis of OSSN as pterygium.https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/119pterigionneoplasias ocularesdiagnóstico clínico |
| spellingShingle | Luis Furuya-Kanamori Carlos M. Dulanto-Reinoso Jennifer C Stone Leila Marroquín Victor Ch. Dulanto-Reinoso José A. Roca Francisco Contreras Graham A. Lee Squamous neoplasia of the ocular surface in patients with pterygium in Peru Revista Peruana de Medicina Experimental y Salud Pública pterigion neoplasias oculares diagnóstico clínico |
| title | Squamous neoplasia of the ocular surface in patients with pterygium in Peru |
| title_full | Squamous neoplasia of the ocular surface in patients with pterygium in Peru |
| title_fullStr | Squamous neoplasia of the ocular surface in patients with pterygium in Peru |
| title_full_unstemmed | Squamous neoplasia of the ocular surface in patients with pterygium in Peru |
| title_short | Squamous neoplasia of the ocular surface in patients with pterygium in Peru |
| title_sort | squamous neoplasia of the ocular surface in patients with pterygium in peru |
| topic | pterigion neoplasias oculares diagnóstico clínico |
| url | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/119 |
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