Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective va...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2011-02-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001&lng=en&tlng=en |
| _version_ | 1818314944998801408 |
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| author | G.A. DosReis |
| author_facet | G.A. DosReis |
| author_sort | G.A. DosReis |
| collection | DOAJ |
| description | Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed. |
| first_indexed | 2024-12-13T08:57:42Z |
| format | Article |
| id | doaj.art-7a58627ad6c44a42b2ea9fffb1b548e0 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-13T08:57:42Z |
| publishDate | 2011-02-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-7a58627ad6c44a42b2ea9fffb1b548e02022-12-21T23:53:15ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2011-02-01442849010.1590/S0100-879X2011000200001S0100-879X2011000200001Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas diseaseG.A. DosReis0Universidade Federal do Rio de JaneiroInfection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001&lng=en&tlng=enTrypanosoma cruziT cellsGPI-anchorsTGF-βMucinApoptosis |
| spellingShingle | G.A. DosReis Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease Brazilian Journal of Medical and Biological Research Trypanosoma cruzi T cells GPI-anchors TGF-β Mucin Apoptosis |
| title | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
| title_full | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
| title_fullStr | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
| title_full_unstemmed | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
| title_short | Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
| title_sort | evasion of immune responses by trypanosoma cruzi the etiological agent of chagas disease |
| topic | Trypanosoma cruzi T cells GPI-anchors TGF-β Mucin Apoptosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001&lng=en&tlng=en |
| work_keys_str_mv | AT gadosreis evasionofimmuneresponsesbytrypanosomacruzitheetiologicalagentofchagasdisease |