Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia
PurposeTo report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).MethodsThis case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Ophthalmology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fopht.2024.1346361/full |
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| author | Samar A. Al-Swailem Hind M. Alkatan Huda Saif AlDhaheri Huda Saif AlDhaheri Sara M. AlHilali Azza M. Y. Maktabi |
| author_facet | Samar A. Al-Swailem Hind M. Alkatan Huda Saif AlDhaheri Huda Saif AlDhaheri Sara M. AlHilali Azza M. Y. Maktabi |
| author_sort | Samar A. Al-Swailem |
| collection | DOAJ |
| description | PurposeTo report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).MethodsThis case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at lost post-treatment visit.ResultsCase 1 was a 45-year-old male who presented with an isolated grayish amoeboid corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C (MMC) 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised using alcohol-assisted epitheliectomy, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months.ConclusionIsolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN. |
| first_indexed | 2024-03-08T09:31:01Z |
| format | Article |
| id | doaj.art-7a58ca41513d4eb0bb9ed15cd58336bd |
| institution | Directory Open Access Journal |
| issn | 2674-0826 |
| language | English |
| last_indexed | 2025-03-20T23:40:38Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Ophthalmology |
| spelling | doaj.art-7a58ca41513d4eb0bb9ed15cd58336bd2024-08-03T13:20:46ZengFrontiers Media S.A.Frontiers in Ophthalmology2674-08262024-01-01410.3389/fopht.2024.13463611346361Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasiaSamar A. Al-Swailem0Hind M. Alkatan1Huda Saif AlDhaheri2Huda Saif AlDhaheri3Sara M. AlHilali4Azza M. Y. Maktabi5Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaOphthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi ArabiaAnterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaOphthalmology Department, Tawam Hospital, Al Ain, United Arab EmiratesAnterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaPathology and Laboratory Medicine, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaPurposeTo report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).MethodsThis case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at lost post-treatment visit.ResultsCase 1 was a 45-year-old male who presented with an isolated grayish amoeboid corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C (MMC) 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised using alcohol-assisted epitheliectomy, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months.ConclusionIsolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN.https://www.frontiersin.org/articles/10.3389/fopht.2024.1346361/fullsquamous cell carcinomaocular surface squamous neoplasiastem cell deficiencyinterferonmitomycin C |
| spellingShingle | Samar A. Al-Swailem Hind M. Alkatan Huda Saif AlDhaheri Huda Saif AlDhaheri Sara M. AlHilali Azza M. Y. Maktabi Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia Frontiers in Ophthalmology squamous cell carcinoma ocular surface squamous neoplasia stem cell deficiency interferon mitomycin C |
| title | Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| title_full | Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| title_fullStr | Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| title_full_unstemmed | Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| title_short | Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| title_sort | case report clinical features and management outcomes of isolated corneal intraepithelial neoplasia |
| topic | squamous cell carcinoma ocular surface squamous neoplasia stem cell deficiency interferon mitomycin C |
| url | https://www.frontiersin.org/articles/10.3389/fopht.2024.1346361/full |
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