Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy
Christina Mueller,1 Ayushe A Sharma,2 Jerzy P Szaflarski3 1Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA; 3Departments of Neurology, Neurobiology, and...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/peripheral-and-central-nervous-system-biomarkers-of-inflammation-in-fu-peer-reviewed-fulltext-article-NDT |
| _version_ | 1797403910885867520 |
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| author | Mueller C Sharma AA Szaflarski JP |
| author_facet | Mueller C Sharma AA Szaflarski JP |
| author_sort | Mueller C |
| collection | DOAJ |
| description | Christina Mueller,1 Ayushe A Sharma,2 Jerzy P Szaflarski3 1Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA; 3Departments of Neurology, Neurobiology, and Neurosurgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USACorrespondence: Christina Mueller, Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, 1719 6th Ave S, Birmingham, AL, 35222, USA, Tel +1 205-975-4219, Fax +1 205-996-4802, Email cm1@uab.eduPurpose: Inflammation may link trauma to clinical symptoms in functional seizures (FS). We compared brain temperature and metabolites in FS, psychiatric (PCs) and healthy controls (HCs) and quantified their associations with serum biomarkers of inflammation and clinical symptoms.Patients and Methods: Brain temperature and metabolites were measured with whole-brain magnetic resonance spectroscopic imaging (MRSI) and compared between groups in regions of interest and the whole brain. Relationships with inflammatory biomarkers and symptoms were assessed with Pearson correlations.Results: Brain temperature was higher in FS than HCs in the orbitofrontal cortex (OFC) and anterior cingulate gyrus (ACG) and lower in the occipital cortex and frontal lobe. PCs showed lower temperatures than HCs in the frontal lobe including precentral gyrus and in the cerebellum. Myo-inositol (MINO) was higher in FS than HCs in the precentral gyrus, posterior temporal gyrus, ACG and OFC, and choline (CHO) was higher in the occipital lobe. CHO was higher in PCs than HCs in the ACG and OFC, and N-acetylaspartate (NAA) was higher in the ACG. There were no significant correlations with the serum inflammatory biomarkers. In FS, brain temperature correlated with depression, quality of life, psychological symptoms, and disability, CHO correlated with disability, and MINO correlated with hostility, disability, and quality of life.Conclusion: Some of the previously identified neuroimaging abnormalities in FS may be related to comorbid psychiatric symptoms, while others, such as abnormalities in sensorimotor cortex, occipital regions, and the temporo-parietal junction may be specific to FS. Overlapping MINO and temperature increases in the ACG and OFC in FS suggest neuroinflammation.Keywords: brain temperature, magnetic resonance spectroscopy, functional seizures, inflammatory biomarkers, metabolites |
| first_indexed | 2024-03-09T02:45:25Z |
| format | Article |
| id | doaj.art-7a5906e67cbb48569cc34f7630a828f8 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-03-09T02:45:25Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-7a5906e67cbb48569cc34f7630a828f82023-12-05T17:06:55ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212023-12-01Volume 192729274388766Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance SpectroscopyMueller CSharma AASzaflarski JPChristina Mueller,1 Ayushe A Sharma,2 Jerzy P Szaflarski3 1Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA; 3Departments of Neurology, Neurobiology, and Neurosurgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USACorrespondence: Christina Mueller, Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, 1719 6th Ave S, Birmingham, AL, 35222, USA, Tel +1 205-975-4219, Fax +1 205-996-4802, Email cm1@uab.eduPurpose: Inflammation may link trauma to clinical symptoms in functional seizures (FS). We compared brain temperature and metabolites in FS, psychiatric (PCs) and healthy controls (HCs) and quantified their associations with serum biomarkers of inflammation and clinical symptoms.Patients and Methods: Brain temperature and metabolites were measured with whole-brain magnetic resonance spectroscopic imaging (MRSI) and compared between groups in regions of interest and the whole brain. Relationships with inflammatory biomarkers and symptoms were assessed with Pearson correlations.Results: Brain temperature was higher in FS than HCs in the orbitofrontal cortex (OFC) and anterior cingulate gyrus (ACG) and lower in the occipital cortex and frontal lobe. PCs showed lower temperatures than HCs in the frontal lobe including precentral gyrus and in the cerebellum. Myo-inositol (MINO) was higher in FS than HCs in the precentral gyrus, posterior temporal gyrus, ACG and OFC, and choline (CHO) was higher in the occipital lobe. CHO was higher in PCs than HCs in the ACG and OFC, and N-acetylaspartate (NAA) was higher in the ACG. There were no significant correlations with the serum inflammatory biomarkers. In FS, brain temperature correlated with depression, quality of life, psychological symptoms, and disability, CHO correlated with disability, and MINO correlated with hostility, disability, and quality of life.Conclusion: Some of the previously identified neuroimaging abnormalities in FS may be related to comorbid psychiatric symptoms, while others, such as abnormalities in sensorimotor cortex, occipital regions, and the temporo-parietal junction may be specific to FS. Overlapping MINO and temperature increases in the ACG and OFC in FS suggest neuroinflammation.Keywords: brain temperature, magnetic resonance spectroscopy, functional seizures, inflammatory biomarkers, metaboliteshttps://www.dovepress.com/peripheral-and-central-nervous-system-biomarkers-of-inflammation-in-fu-peer-reviewed-fulltext-article-NDTbrain temperaturemagnetic resonance spectroscopyfunctional seizuresinflammatory biomarkersmetabolites |
| spellingShingle | Mueller C Sharma AA Szaflarski JP Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy Neuropsychiatric Disease and Treatment brain temperature magnetic resonance spectroscopy functional seizures inflammatory biomarkers metabolites |
| title | Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy |
| title_full | Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy |
| title_fullStr | Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy |
| title_full_unstemmed | Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy |
| title_short | Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy |
| title_sort | peripheral and central nervous system biomarkers of inflammation in functional seizures assessment with magnetic resonance spectroscopy |
| topic | brain temperature magnetic resonance spectroscopy functional seizures inflammatory biomarkers metabolites |
| url | https://www.dovepress.com/peripheral-and-central-nervous-system-biomarkers-of-inflammation-in-fu-peer-reviewed-fulltext-article-NDT |
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