Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH

Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH

Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals with fumaric acid and succinic acid as functions...

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Bibliographic Details
Main Authors: Jaydip M. Vasoya, Ankita V. Shah, Abu T.M. Serajuddin
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2019-04-01
Series:ADMET and DMPK
Subjects:
Ketoconazole
cocrystal
solubility
pH effect
intrinsic dissolution rate
solid phase
phase conversion
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/661

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