Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells
Summary: Toll signaling is well known for its pivotal role in the host response against the invasion of external pathogens. Here, we investigate the potential involvement of Toll signaling in the intersection between the host and oncogenic cells. We show that loss of myeloid differentiation factor 8...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000056 |
| _version_ | 1797291774983536640 |
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| author | Shanming Ji Xiaojing Zhou Jules A. Hoffmann |
| author_facet | Shanming Ji Xiaojing Zhou Jules A. Hoffmann |
| author_sort | Shanming Ji |
| collection | DOAJ |
| description | Summary: Toll signaling is well known for its pivotal role in the host response against the invasion of external pathogens. Here, we investigate the potential involvement of Toll signaling in the intersection between the host and oncogenic cells. We show that loss of myeloid differentiation factor 88 (Myd88) leads to drastic fly death after the injection of RasV12-GFP oncogenic cells. Transcriptomic analyses show that challenging flies with oncogenic cells or bacteria leads to distinct inductions of Myd88-dependent genes. We note that downregulation of Myd88 in the tracheal system accounts for fly mortality, and ectopic tracheal complementation of Myd88 rescues the survival defect in Myd88 loss-of-function mutants following RasV12-GFP injection. Further, molecular and genetic evidence indicate that Toll signaling modulates fly resistance to RasV12-GFP cells through mediating airway function in a rolled-dependent manner. Collectively, our data indicate a critical role of Toll signaling in tracheal homeostasis and host survival after the injection of oncogenic cells. |
| first_indexed | 2024-03-07T19:42:34Z |
| format | Article |
| id | doaj.art-7a592ff38e444a9ab1419afce1a475d6 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:34Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-7a592ff38e444a9ab1419afce1a475d62024-02-29T05:18:33ZengElsevierCell Reports2211-12472024-02-01432113677Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cellsShanming Ji0Xiaojing Zhou1Jules A. Hoffmann2Insect Models of Innate Immunity (M3I; 9022), Institute of Molecular and Cellular Biology, CNRS, 67084 Strasbourg, FranceSino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, ChinaInsect Models of Innate Immunity (M3I; 9022), Institute of Molecular and Cellular Biology, CNRS, 67084 Strasbourg, France; Institute for Advanced Study, University of Strasbourg, 67000 Strasbourg, France; Sino-French Hoffmann Institute, School of Basic Medical Science, Guangzhou Medical University, Guangzhou 511436, China; Corresponding authorSummary: Toll signaling is well known for its pivotal role in the host response against the invasion of external pathogens. Here, we investigate the potential involvement of Toll signaling in the intersection between the host and oncogenic cells. We show that loss of myeloid differentiation factor 88 (Myd88) leads to drastic fly death after the injection of RasV12-GFP oncogenic cells. Transcriptomic analyses show that challenging flies with oncogenic cells or bacteria leads to distinct inductions of Myd88-dependent genes. We note that downregulation of Myd88 in the tracheal system accounts for fly mortality, and ectopic tracheal complementation of Myd88 rescues the survival defect in Myd88 loss-of-function mutants following RasV12-GFP injection. Further, molecular and genetic evidence indicate that Toll signaling modulates fly resistance to RasV12-GFP cells through mediating airway function in a rolled-dependent manner. Collectively, our data indicate a critical role of Toll signaling in tracheal homeostasis and host survival after the injection of oncogenic cells.http://www.sciencedirect.com/science/article/pii/S2211124724000056CP: CancerCP: Immunology |
| spellingShingle | Shanming Ji Xiaojing Zhou Jules A. Hoffmann Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells Cell Reports CP: Cancer CP: Immunology |
| title | Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells |
| title_full | Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells |
| title_fullStr | Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells |
| title_full_unstemmed | Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells |
| title_short | Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells |
| title_sort | toll mediated airway homeostasis is essential for fly survival upon injection of rasv12 gfp oncogenic cells |
| topic | CP: Cancer CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724000056 |
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