Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?
<p>Abstract</p> <p>The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confir...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-01-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | http://www.jneuroinflammation.com/content/9/1/20 |
| _version_ | 1828747017878241280 |
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| author | Li Grace Esiri Margaret M Ansorge Olaf DeLuca Gabriele C |
| author_facet | Li Grace Esiri Margaret M Ansorge Olaf DeLuca Gabriele C |
| author_sort | Li Grace |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confirmed concurrent MS and ALS.</p> <p>This is the most pathologically illustrative case of coincident MS and ALS demonstrating inflammatory and neurodegenerative features characteristic of each disease, and is the first to exhibit the presence of TDP-43 inclusions in this clinical entity. The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.</p> |
| first_indexed | 2024-04-14T04:35:04Z |
| format | Article |
| id | doaj.art-7a5a4c4f4eec414883e0f6e9bcec36cc |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-14T04:35:04Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-7a5a4c4f4eec414883e0f6e9bcec36cc2022-12-22T02:11:55ZengBMCJournal of Neuroinflammation1742-20942012-01-01912010.1186/1742-2094-9-20Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?Li GraceEsiri Margaret MAnsorge OlafDeLuca Gabriele C<p>Abstract</p> <p>The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confirmed concurrent MS and ALS.</p> <p>This is the most pathologically illustrative case of coincident MS and ALS demonstrating inflammatory and neurodegenerative features characteristic of each disease, and is the first to exhibit the presence of TDP-43 inclusions in this clinical entity. The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.</p>http://www.jneuroinflammation.com/content/9/1/20multiple sclerosisamyotrophic lateral sclerosisneuropathologyinflammationneurodegeneration |
| spellingShingle | Li Grace Esiri Margaret M Ansorge Olaf DeLuca Gabriele C Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? Journal of Neuroinflammation multiple sclerosis amyotrophic lateral sclerosis neuropathology inflammation neurodegeneration |
| title | Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? |
| title_full | Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? |
| title_fullStr | Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? |
| title_full_unstemmed | Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? |
| title_short | Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? |
| title_sort | concurrent multiple sclerosis and amyotrophic lateral sclerosis where inflammation and neurodegeneration meet |
| topic | multiple sclerosis amyotrophic lateral sclerosis neuropathology inflammation neurodegeneration |
| url | http://www.jneuroinflammation.com/content/9/1/20 |
| work_keys_str_mv | AT ligrace concurrentmultiplesclerosisandamyotrophiclateralsclerosiswhereinflammationandneurodegenerationmeet AT esirimargaretm concurrentmultiplesclerosisandamyotrophiclateralsclerosiswhereinflammationandneurodegenerationmeet AT ansorgeolaf concurrentmultiplesclerosisandamyotrophiclateralsclerosiswhereinflammationandneurodegenerationmeet AT delucagabrielec concurrentmultiplesclerosisandamyotrophiclateralsclerosiswhereinflammationandneurodegenerationmeet |