Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress
Neural stem cells, the progenitors of the nervous system, control distinct, position-specific functions and are critically involved in the maintenance of homeostasis in the brain. The responses of these cells to various stressful stimuli are shaped by genetic, epigenetic and environmental factors vi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00077/full |
| _version_ | 1818931510484402176 |
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| author | Yassemi eKoutmani Katia eKaralis |
| author_facet | Yassemi eKoutmani Katia eKaralis |
| author_sort | Yassemi eKoutmani |
| collection | DOAJ |
| description | Neural stem cells, the progenitors of the nervous system, control distinct, position-specific functions and are critically involved in the maintenance of homeostasis in the brain. The responses of these cells to various stressful stimuli are shaped by genetic, epigenetic and environmental factors via mechanisms that are age and developmental stage-dependent and still remain, to a great extent, elusive. Increasing evidence advocates for the beneficial impact of the stress response in various settings, complementing the extensive number of studies on the detrimental effects of stress, particularly in the developing brain. In this review, we discuss suggested mechanisms mediating both the beneficial and detrimental effects of stressors on neural stem cell activity across the lifespan. We focus on the specific effects of secreted factors and we propose neural stem cells as a sensor, capable of distinguishing among the different stressors and adapting its functions accordingly. All the above suggest the intriguing hypothesis that neural stem cells are an important part of the adaptive response to stressors via direct and indirect, specific mechanisms. |
| first_indexed | 2024-12-20T04:17:44Z |
| format | Article |
| id | doaj.art-7a609ff0a4ac478ca581581ddb52f6e0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T04:17:44Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7a609ff0a4ac478ca581581ddb52f6e02022-12-21T19:53:44ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-03-01610.3389/fphys.2015.00077137413Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stressYassemi eKoutmani0Katia eKaralis1Biomedical Research Foundation, Academy of AthensBiomedical Research Foundation, Academy of AthensNeural stem cells, the progenitors of the nervous system, control distinct, position-specific functions and are critically involved in the maintenance of homeostasis in the brain. The responses of these cells to various stressful stimuli are shaped by genetic, epigenetic and environmental factors via mechanisms that are age and developmental stage-dependent and still remain, to a great extent, elusive. Increasing evidence advocates for the beneficial impact of the stress response in various settings, complementing the extensive number of studies on the detrimental effects of stress, particularly in the developing brain. In this review, we discuss suggested mechanisms mediating both the beneficial and detrimental effects of stressors on neural stem cell activity across the lifespan. We focus on the specific effects of secreted factors and we propose neural stem cells as a sensor, capable of distinguishing among the different stressors and adapting its functions accordingly. All the above suggest the intriguing hypothesis that neural stem cells are an important part of the adaptive response to stressors via direct and indirect, specific mechanisms.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00077/fullNeural Stem Cellsglucocorticoidstressadult neurogenesisstress hormonesNervous System Development |
| spellingShingle | Yassemi eKoutmani Katia eKaralis Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress Frontiers in Physiology Neural Stem Cells glucocorticoid stress adult neurogenesis stress hormones Nervous System Development |
| title | Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress |
| title_full | Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress |
| title_fullStr | Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress |
| title_full_unstemmed | Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress |
| title_short | Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress |
| title_sort | neural stem cells respond to stress hormones distinguishing beneficial from detrimental stress |
| topic | Neural Stem Cells glucocorticoid stress adult neurogenesis stress hormones Nervous System Development |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00077/full |
| work_keys_str_mv | AT yassemiekoutmani neuralstemcellsrespondtostresshormonesdistinguishingbeneficialfromdetrimentalstress AT katiaekaralis neuralstemcellsrespondtostresshormonesdistinguishingbeneficialfromdetrimentalstress |