RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression
AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the func...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2022-04-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac082 |
| Summary: | AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the functions of these complexes remains largely unknown. We generated viable Rbbp4Rbbp4 |
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| ISSN: | 2160-1836 |