RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression
AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the func...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2022-04-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac082 |
| _version_ | 1811295230887985152 |
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| author | Weipeng Mu Noel S Murcia Keriayn N Smith Debashish U Menon Della Yee Terry Magnuson |
| author_facet | Weipeng Mu Noel S Murcia Keriayn N Smith Debashish U Menon Della Yee Terry Magnuson |
| author_sort | Weipeng Mu |
| collection | DOAJ |
| description |
AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the functions of these complexes remains largely unknown. We generated viable Rbbp4Rbbp4 |
| first_indexed | 2024-04-13T05:29:31Z |
| format | Article |
| id | doaj.art-7a61712067e6401693d2b9778cf11eb2 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-04-13T05:29:31Z |
| publishDate | 2022-04-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-7a61712067e6401693d2b9778cf11eb22022-12-22T03:00:29ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362022-04-0112610.1093/g3journal/jkac082RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expressionWeipeng Mu0https://orcid.org/0000-0001-5165-9292Noel S Murcia1https://orcid.org/0000-0003-1931-6235Keriayn N Smith2https://orcid.org/0000-0002-4351-2765Debashish U Menon3https://orcid.org/0000-0003-3052-9872Della Yee4https://orcid.org/0000-0002-2304-9873Terry Magnuson5https://orcid.org/0000-0002-0792-835XDepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USADepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USADepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USADepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USADepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USADepartment of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264, USA AbstractRBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive complex 2 and histone deacetylase 1/2-containing complexes. These complexes are responsible for histone H3 lysine 27 methylation and deacetylation, respectively. How RBBP4 modulates the functions of these complexes remains largely unknown. We generated viable Rbbp4Rbbp4https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac082 |
| spellingShingle | Weipeng Mu Noel S Murcia Keriayn N Smith Debashish U Menon Della Yee Terry Magnuson RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression G3: Genes, Genomes, Genetics |
| title | RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression |
| title_full | RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression |
| title_fullStr | RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression |
| title_full_unstemmed | RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression |
| title_short | RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression |
| title_sort | rbbp4 dysfunction reshapes the genomic landscape of h3k27 methylation and acetylation and disrupts gene expression |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkac082 |
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