Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know
Human papillomavirus (HPV) infections cause a significant proportion of cancers worldwide, predominantly squamous cell carcinomas (SCC) of the mucosas and skin. High-risk HPV types are associated with SCCs of the anogenital and oropharyngeal tract. HPV oncogene activities and the biology of SCCs hav...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/10/1/47 |
| _version_ | 1818931510946824192 |
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| author | Ruby Khoury Sharon Sauter Melinda Butsch Kovacic Adam S. Nelson Kasiani C. Myers Parinda A. Mehta Stella M. Davies Susanne I. Wells |
| author_facet | Ruby Khoury Sharon Sauter Melinda Butsch Kovacic Adam S. Nelson Kasiani C. Myers Parinda A. Mehta Stella M. Davies Susanne I. Wells |
| author_sort | Ruby Khoury |
| collection | DOAJ |
| description | Human papillomavirus (HPV) infections cause a significant proportion of cancers worldwide, predominantly squamous cell carcinomas (SCC) of the mucosas and skin. High-risk HPV types are associated with SCCs of the anogenital and oropharyngeal tract. HPV oncogene activities and the biology of SCCs have been intensely studied in laboratory models and humans. What remains largely unknown are host tissue and immune-related factors that determine an individual’s susceptibility to infection and/or carcinogenesis. Such susceptibility factors could serve to identify those at greatest risk and spark individually tailored HPV and SCC prevention efforts. Fanconi anemia (FA) is an inherited DNA repair disorder that is in part characterized by extreme susceptibility to SCCs. An increased prevalence of HPV has been reported in affected individuals, and molecular and functional connections between FA, SCC, and HPV were established in laboratory models. However, the presence of HPV in some human FA tumors is controversial, and the extent of the etiological connections remains to be established. Herein, we discuss cellular, immunological, and phenotypic features of FA, placed into the context of HPV pathogenesis. The goal is to highlight this orphan disease as a unique model system to uncover host genetic and molecular HPV features, as well as SCC susceptibility factors. |
| first_indexed | 2024-12-20T04:17:45Z |
| format | Article |
| id | doaj.art-7a64481ec6e5450ea83fc6e1d384e511 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T04:17:45Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-7a64481ec6e5450ea83fc6e1d384e5112022-12-21T19:53:44ZengMDPI AGViruses1999-49152018-01-011014710.3390/v10010047v10010047Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We KnowRuby Khoury0Sharon Sauter1Melinda Butsch Kovacic2Adam S. Nelson3Kasiani C. Myers4Parinda A. Mehta5Stella M. Davies6Susanne I. Wells7Divisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivisions of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAHuman papillomavirus (HPV) infections cause a significant proportion of cancers worldwide, predominantly squamous cell carcinomas (SCC) of the mucosas and skin. High-risk HPV types are associated with SCCs of the anogenital and oropharyngeal tract. HPV oncogene activities and the biology of SCCs have been intensely studied in laboratory models and humans. What remains largely unknown are host tissue and immune-related factors that determine an individual’s susceptibility to infection and/or carcinogenesis. Such susceptibility factors could serve to identify those at greatest risk and spark individually tailored HPV and SCC prevention efforts. Fanconi anemia (FA) is an inherited DNA repair disorder that is in part characterized by extreme susceptibility to SCCs. An increased prevalence of HPV has been reported in affected individuals, and molecular and functional connections between FA, SCC, and HPV were established in laboratory models. However, the presence of HPV in some human FA tumors is controversial, and the extent of the etiological connections remains to be established. Herein, we discuss cellular, immunological, and phenotypic features of FA, placed into the context of HPV pathogenesis. The goal is to highlight this orphan disease as a unique model system to uncover host genetic and molecular HPV features, as well as SCC susceptibility factors.http://www.mdpi.com/1999-4915/10/1/47human papillomavirusFanconi anemiaorphan diseasesquamous cell carcinomainherited cancer susceptibility |
| spellingShingle | Ruby Khoury Sharon Sauter Melinda Butsch Kovacic Adam S. Nelson Kasiani C. Myers Parinda A. Mehta Stella M. Davies Susanne I. Wells Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know Viruses human papillomavirus Fanconi anemia orphan disease squamous cell carcinoma inherited cancer susceptibility |
| title | Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know |
| title_full | Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know |
| title_fullStr | Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know |
| title_full_unstemmed | Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know |
| title_short | Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know |
| title_sort | risk of human papillomavirus infection in cancer prone individuals what we know |
| topic | human papillomavirus Fanconi anemia orphan disease squamous cell carcinoma inherited cancer susceptibility |
| url | http://www.mdpi.com/1999-4915/10/1/47 |
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