NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS

<p><strong>Aim.</strong> To determine the main mechanisms of chronic pericarditis (CP) on the basis of chronic pericardium inflammation study with morphological, laboratory and instrumental methods.</p><p><strong>Material and methods.</strong> 139 patients w...

Full description

Bibliographic Details
Main Authors: V. V. Kochmasheva, E. D. Rozhdestvenskaya, E. S. Belikov, M. A. Dergunova, M. V. Arhipov
Format: Article
Language:English
Published: Столичная издательская компания 2016-01-01
Series:Рациональная фармакотерапия в кардиологии
Subjects:
Online Access:http://www.rpcardio.ru/jour/article/view/619
_version_ 1797699864788729856
author V. V. Kochmasheva
E. D. Rozhdestvenskaya
E. S. Belikov
M. A. Dergunova
M. V. Arhipov
author_facet V. V. Kochmasheva
E. D. Rozhdestvenskaya
E. S. Belikov
M. A. Dergunova
M. V. Arhipov
author_sort V. V. Kochmasheva
collection DOAJ
description <p><strong>Aim.</strong> To determine the main mechanisms of chronic pericarditis (CP) on the basis of chronic pericardium inflammation study with morphological, laboratory and instrumental methods.</p><p><strong>Material and methods.</strong> 139 patients with CP were involved in the study. The analysis of clinical data, results of laboratory and instrumental examination as well as morphological data of 27 pericardectomies was performed.</p><p><strong>Results.</strong> The morphological features in 92,5% of cases did not depend on disease aetiology. Inflammation signs are founded in 74,1% of pericardium samples. Inflammatory reaction of adjacent fatty tissue and changes of the pericardium nervous system also was revealed. The levels of immune status markers in patients with CP significantly depended on inflammation activity and they did not depend on disease causes. Anti-inflammatory cytokine levels (receptor antagonist of IL-1 alpha (RAIL-1 alpha) above 700 pg/ml is founded in patients with subclinical disease feature. RAIL level below 300 pg/ml took place in serious and recurring CP.</p><p><strong>Conclusion.</strong> CP is a result of pericardium inflammation with involving adjacent fatty tissue and with changes of the pericardium nervous system. Relationship between disease clinical course and RAIL-1 level was found. CP progression and new pathogenesis mechanisms is discussed. </p>
first_indexed 2024-03-12T04:13:57Z
format Article
id doaj.art-7a68dcb0e7ed4f80a83fddd760567198
institution Directory Open Access Journal
issn 1819-6446
2225-3653
language English
last_indexed 2024-03-12T04:13:57Z
publishDate 2016-01-01
publisher Столичная издательская компания
record_format Article
series Рациональная фармакотерапия в кардиологии
spelling doaj.art-7a68dcb0e7ed4f80a83fddd7605671982023-09-03T10:44:36ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0152495410.1234/1819-6446-2009-2-49-54618NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITISV. V. Kochmasheva0E. D. Rozhdestvenskaya1E. S. Belikov2M. A. Dergunova3M. V. Arhipov4Свердловская областная клиническая больница №1Уральская государственная медицинская академияСвердловское областное патологоанатомическое бюроСвердловское областное патологоанатомическое бюроУральская государственная медицинская академия<p><strong>Aim.</strong> To determine the main mechanisms of chronic pericarditis (CP) on the basis of chronic pericardium inflammation study with morphological, laboratory and instrumental methods.</p><p><strong>Material and methods.</strong> 139 patients with CP were involved in the study. The analysis of clinical data, results of laboratory and instrumental examination as well as morphological data of 27 pericardectomies was performed.</p><p><strong>Results.</strong> The morphological features in 92,5% of cases did not depend on disease aetiology. Inflammation signs are founded in 74,1% of pericardium samples. Inflammatory reaction of adjacent fatty tissue and changes of the pericardium nervous system also was revealed. The levels of immune status markers in patients with CP significantly depended on inflammation activity and they did not depend on disease causes. Anti-inflammatory cytokine levels (receptor antagonist of IL-1 alpha (RAIL-1 alpha) above 700 pg/ml is founded in patients with subclinical disease feature. RAIL level below 300 pg/ml took place in serious and recurring CP.</p><p><strong>Conclusion.</strong> CP is a result of pericardium inflammation with involving adjacent fatty tissue and with changes of the pericardium nervous system. Relationship between disease clinical course and RAIL-1 level was found. CP progression and new pathogenesis mechanisms is discussed. </p>http://www.rpcardio.ru/jour/article/view/619хронический перикардитэтиологияморфологические изменениявоспалениеинтерлейкины
spellingShingle V. V. Kochmasheva
E. D. Rozhdestvenskaya
E. S. Belikov
M. A. Dergunova
M. V. Arhipov
NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
Рациональная фармакотерапия в кардиологии
хронический перикардит
этиология
морфологические изменения
воспаление
интерлейкины
title NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
title_full NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
title_fullStr NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
title_full_unstemmed NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
title_short NEW PATHOGENIC MECHANISMS OF THE CHRONIC PERICARDITIS
title_sort new pathogenic mechanisms of the chronic pericarditis
topic хронический перикардит
этиология
морфологические изменения
воспаление
интерлейкины
url http://www.rpcardio.ru/jour/article/view/619
work_keys_str_mv AT vvkochmasheva newpathogenicmechanismsofthechronicpericarditis
AT edrozhdestvenskaya newpathogenicmechanismsofthechronicpericarditis
AT esbelikov newpathogenicmechanismsofthechronicpericarditis
AT madergunova newpathogenicmechanismsofthechronicpericarditis
AT mvarhipov newpathogenicmechanismsofthechronicpericarditis