Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19)
INTRODUCTION: Coronavirus disease 2019 (COVID-19), a global pandemic with catastrophic consequences for healthcare systems causing serious respiratory illness, was first reported in China. Early identification of severe illness is critical for controlling it and improving the prognosis of patients....
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| Format: | Article |
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KARE Publishing
2022-01-01
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| Series: | International Journal of Medical Biochemistry |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=ijmb&un=IJMB-57070 |
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| author | Çiğdem Damla Deniz Nahide Baran Ayse Rüveyda Ugur Ahmet Güneyk Mehmet Özcan İsmail Hakkı Tunçez Mehmet Koç |
| author_facet | Çiğdem Damla Deniz Nahide Baran Ayse Rüveyda Ugur Ahmet Güneyk Mehmet Özcan İsmail Hakkı Tunçez Mehmet Koç |
| author_sort | Çiğdem Damla Deniz |
| collection | DOAJ |
| description | INTRODUCTION: Coronavirus disease 2019 (COVID-19), a global pandemic with catastrophic consequences for healthcare systems causing serious respiratory illness, was first reported in China. Early identification of severe illness is critical for controlling it and improving the prognosis of patients. In this study, we aimed to evaluate the prognostic value of Creactive protein (CRP)/albumin ratio and to investigate the usability of this ratio in COVID-19. METHODS: This was a retrospective cohort study of 1077 patients. The statistical significance was calculated using Mann-Whitney U test. The correlations between CRP/albumin ratio and other datas were evaluated by Spearman's rho test. We evaluated the prognostic value of CRP/albumin ratio using the Chi-Square test and Cox regression analysis. RESULTS: Higher CRP/albumin ratio levels were associated with long-term hospitalization in COVID-19. When the results of the receiver operating characteristic analysis were examined for all laboratory parameters, the area under the curve value of the CRP/albumin ratio, procalcitonin, CRP, and albumin were 0.85, 0.64, 0.86, and 0.81, respectively. The survival mortality cut-off value for CRP/albumin ratio was determined as 1.895. When evaluated by Cox regression analysis (cutoff value: 1.895, p<0.0001), the CRP/albumin ratio was found to be independently associated with in-hospital mortality. DISCUSSION AND CONCLUSION: We showed that the CRP/albumin ratio is a useful prognostic marker this marker can be used in predicting the severity of COVID-19. |
| first_indexed | 2024-04-10T14:51:17Z |
| format | Article |
| id | doaj.art-7a696864bc1d4724a5ff3c7f4cea3dce |
| institution | Directory Open Access Journal |
| issn | 2587-2362 |
| language | English |
| last_indexed | 2024-04-10T14:51:17Z |
| publishDate | 2022-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | International Journal of Medical Biochemistry |
| spelling | doaj.art-7a696864bc1d4724a5ff3c7f4cea3dce2023-02-15T16:07:36ZengKARE PublishingInternational Journal of Medical Biochemistry2587-23622022-01-015181410.14744/ijmb.2021.57070IJMB-57070Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19)Çiğdem Damla Deniz0Nahide Baran1Ayse Rüveyda Ugur2Ahmet Güneyk3Mehmet Özcan4İsmail Hakkı Tunçez5Mehmet Koç6Department Of Medical Biochemistry, Konya City Hospital, Konya, TurkeyDepartment Of Radiology, Cihanbeyli State Hospital, Konya, TurkeyDepartment Of Microbiology, Konya City Hospital, Konya, TurkeyDepartment Of Medical Biochemistry, Konya City Hospital, Konya, TurkeyDepartment Of Infectious Diseases And Clinical Microbiology, Konya State Hospital, KonyaDepartment Of Public Health, Konya Provincial Health Directorate, Konya, TurkeyDepartment Of Radiation Oncology, Meram School Of Medicine, Necmettin Erbakan University, Konya, TurkeyINTRODUCTION: Coronavirus disease 2019 (COVID-19), a global pandemic with catastrophic consequences for healthcare systems causing serious respiratory illness, was first reported in China. Early identification of severe illness is critical for controlling it and improving the prognosis of patients. In this study, we aimed to evaluate the prognostic value of Creactive protein (CRP)/albumin ratio and to investigate the usability of this ratio in COVID-19. METHODS: This was a retrospective cohort study of 1077 patients. The statistical significance was calculated using Mann-Whitney U test. The correlations between CRP/albumin ratio and other datas were evaluated by Spearman's rho test. We evaluated the prognostic value of CRP/albumin ratio using the Chi-Square test and Cox regression analysis. RESULTS: Higher CRP/albumin ratio levels were associated with long-term hospitalization in COVID-19. When the results of the receiver operating characteristic analysis were examined for all laboratory parameters, the area under the curve value of the CRP/albumin ratio, procalcitonin, CRP, and albumin were 0.85, 0.64, 0.86, and 0.81, respectively. The survival mortality cut-off value for CRP/albumin ratio was determined as 1.895. When evaluated by Cox regression analysis (cutoff value: 1.895, p<0.0001), the CRP/albumin ratio was found to be independently associated with in-hospital mortality. DISCUSSION AND CONCLUSION: We showed that the CRP/albumin ratio is a useful prognostic marker this marker can be used in predicting the severity of COVID-19.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=ijmb&un=IJMB-57070albumincovid-19c-reactive proteinc-reactive protein/albumin ratiohospitalization |
| spellingShingle | Çiğdem Damla Deniz Nahide Baran Ayse Rüveyda Ugur Ahmet Güneyk Mehmet Özcan İsmail Hakkı Tunçez Mehmet Koç Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) International Journal of Medical Biochemistry albumin covid-19 c-reactive protein c-reactive protein/albumin ratio hospitalization |
| title | Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) |
| title_full | Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) |
| title_fullStr | Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) |
| title_full_unstemmed | Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) |
| title_short | Evaluation of the relationship between C-Reactive Protein/Albumin Ratio and Hospitalization in Novel Coronavirus disease-19 (COVID-19) |
| title_sort | evaluation of the relationship between c reactive protein albumin ratio and hospitalization in novel coronavirus disease 19 covid 19 |
| topic | albumin covid-19 c-reactive protein c-reactive protein/albumin ratio hospitalization |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=ijmb&un=IJMB-57070 |
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