Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

To augment HIV-1 pox-protein vaccine immunogenicity using a next generation adjuvant, a prime-boost strategy of recombinant modified vaccinia virus Ankara and multimeric Env gp145 was evaluated in macaques with either aluminum (alum) or a novel liposomal monophosphoryl lipid A (MPLA) formulation ads...

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Bibliographic Details
Main Authors: Kier Om, Dominic Paquin-Proulx, Maria Montero, Kristina Peachman, Xiaoying Shen, Lindsay Wieczorek, Zoltan Beck, Joshua A Weiner, Dohoon Kim, Yifan Li, Thembi Mdluli, Zhanna Shubin, Christopher Bryant, Vishakha Sharma, Andrey Tokarev, Peter Dawson, Yohann White, Oliver Appelbe, Nichole R Klatt, Sodsai Tovanabutra, Jacob D Estes, Gary R Matyas, Guido Ferrari, Carl R Alving, Georgia D Tomaras, Margaret E Ackerman, Nelson L Michael, Merlin L Robb, Victoria Polonis, Morgane Rolland, Michael A Eller, Mangala Rao, Diane L Bolton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008764

Internet

https://doi.org/10.1371/journal.ppat.1008764

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