Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody
A man with non-small-cell lung cancer who was negative for anti-nuclear antibodies was admitted for dyspnea after immune checkpoint inhibitor (ICI) administration. Computed tomography (CT) showed complexed radiologic features, including subpleural and basal predominant reticular shadow with cystic s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007122002192 |
| _version_ | 1828068334945435648 |
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| author | Seiya Ichihara Hirokazu Ogino Hiroto Yoneda Keiko Haji Kozo Kagawa Kojin Murakami Masato Mima Yu Aoi Atsushi Mitsuhashi Yuki Tsukazaki Yohei Yabuki Ryohiko Ozaki Seidai Sato Hiroshi Nokihara Yasuhiko Nishioka |
| author_facet | Seiya Ichihara Hirokazu Ogino Hiroto Yoneda Keiko Haji Kozo Kagawa Kojin Murakami Masato Mima Yu Aoi Atsushi Mitsuhashi Yuki Tsukazaki Yohei Yabuki Ryohiko Ozaki Seidai Sato Hiroshi Nokihara Yasuhiko Nishioka |
| author_sort | Seiya Ichihara |
| collection | DOAJ |
| description | A man with non-small-cell lung cancer who was negative for anti-nuclear antibodies was admitted for dyspnea after immune checkpoint inhibitor (ICI) administration. Computed tomography (CT) showed complexed radiologic features, including subpleural and basal predominant reticular shadow with cystic structures and peribronchovascular consolidation. Although we treated him with high-dose steroid under a diagnosis of ICI-related pneumonitis, he developed acute exacerbation of pneumonitis with progressive fibrosis and volume loss. A re-evaluation identified anti-aminoacyl-tRNA synthetase antibody in the serum collected before ICI administration. This case highlights the importance of re-evaluating pre-existing autoimmune disorders in patients who develop ICI-related pneumonitis with atypical radiologic features. |
| first_indexed | 2024-04-11T00:01:11Z |
| format | Article |
| id | doaj.art-7a6cbd5292674aa692a63a3ed843bb40 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-11T00:01:11Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-7a6cbd5292674aa692a63a3ed843bb402023-01-10T04:05:57ZengElsevierRespiratory Medicine Case Reports2213-00712023-01-0141101797Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibodySeiya Ichihara0Hirokazu Ogino1Hiroto Yoneda2Keiko Haji3Kozo Kagawa4Kojin Murakami5Masato Mima6Yu Aoi7Atsushi Mitsuhashi8Yuki Tsukazaki9Yohei Yabuki10Ryohiko Ozaki11Seidai Sato12Hiroshi Nokihara13Yasuhiko Nishioka14Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanDepartment of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanCorresponding author.; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, JapanA man with non-small-cell lung cancer who was negative for anti-nuclear antibodies was admitted for dyspnea after immune checkpoint inhibitor (ICI) administration. Computed tomography (CT) showed complexed radiologic features, including subpleural and basal predominant reticular shadow with cystic structures and peribronchovascular consolidation. Although we treated him with high-dose steroid under a diagnosis of ICI-related pneumonitis, he developed acute exacerbation of pneumonitis with progressive fibrosis and volume loss. A re-evaluation identified anti-aminoacyl-tRNA synthetase antibody in the serum collected before ICI administration. This case highlights the importance of re-evaluating pre-existing autoimmune disorders in patients who develop ICI-related pneumonitis with atypical radiologic features.http://www.sciencedirect.com/science/article/pii/S2213007122002192Non-small-cell lung cancerImmune checkpoint inhibitorPneumonitisAnti-aminoacyl-tRNA synthetase antibody |
| spellingShingle | Seiya Ichihara Hirokazu Ogino Hiroto Yoneda Keiko Haji Kozo Kagawa Kojin Murakami Masato Mima Yu Aoi Atsushi Mitsuhashi Yuki Tsukazaki Yohei Yabuki Ryohiko Ozaki Seidai Sato Hiroshi Nokihara Yasuhiko Nishioka Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody Respiratory Medicine Case Reports Non-small-cell lung cancer Immune checkpoint inhibitor Pneumonitis Anti-aminoacyl-tRNA synthetase antibody |
| title | Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody |
| title_full | Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody |
| title_fullStr | Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody |
| title_full_unstemmed | Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody |
| title_short | Immune checkpoint inhibitor-related pneumonitis with atypical radiologic features in a patient with anti-aminoacyl-tRNA synthetase antibody |
| title_sort | immune checkpoint inhibitor related pneumonitis with atypical radiologic features in a patient with anti aminoacyl trna synthetase antibody |
| topic | Non-small-cell lung cancer Immune checkpoint inhibitor Pneumonitis Anti-aminoacyl-tRNA synthetase antibody |
| url | http://www.sciencedirect.com/science/article/pii/S2213007122002192 |
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