Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing
Abstract A three‐step electrochemical process is developed to grow a coating on Ti6Al4V alloy for biomedical applications aimed to enhance its bioactivity. The coating is composed by a porous titanium oxide filled with Ag, alginic acid, and hydroxyapatite to provide antibacterial properties and, at...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-01-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202201725 |
| _version_ | 1797730817321992192 |
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| author | Davide Pupillo Andrea Zaffora Francesco Di Franco Pasquale Picone Domenico Nuzzo Monica Santamaria |
| author_facet | Davide Pupillo Andrea Zaffora Francesco Di Franco Pasquale Picone Domenico Nuzzo Monica Santamaria |
| author_sort | Davide Pupillo |
| collection | DOAJ |
| description | Abstract A three‐step electrochemical process is developed to grow a coating on Ti6Al4V alloy for biomedical applications aimed to enhance its bioactivity. The coating is composed by a porous titanium oxide filled with Ag, alginic acid, and hydroxyapatite to provide antibacterial properties and, at the same time, osteointegration capability. Anodized and treated with the electrochemical process samples are characterized by Scanning Electron Microscopy (SEM), Energy‐Dispersive X‐ray Spectroscopy (EDX), X‐Ray Diffraction, and Raman Spectroscopy to have information about morphology and composition soon after the fabrication and after immersion in Hanks’ solution. Bioactivity of the samples is also proved by electrochemical tests through Electrochemical Impedance Spectroscopy (EIS) measurements. Antibacterial properties, cytocompatibility and hemocompatibility of the samples are successfully demonstrated by in vitro tests. |
| first_indexed | 2024-03-12T11:50:40Z |
| format | Article |
| id | doaj.art-7a6f45626a1a430d9bb507e7badac2a9 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T11:50:40Z |
| publishDate | 2023-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-7a6f45626a1a430d9bb507e7badac2a92023-08-31T09:03:06ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-01-01102n/an/a10.1002/admi.202201725Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark AnodizingDavide Pupillo0Andrea Zaffora1Francesco Di Franco2Pasquale Picone3Domenico Nuzzo4Monica Santamaria5Politecnico di Torino Dipartimento di Scienza Applicata e Tecnologia Corso Duca degli Abruzzi 24 Torino 10129 ItalyUniversità degli Studi di Palermo Dipartimento di Ingegneria Viale delle Scienze, Ed. 6 Palermo 90128 ItalyUniversità degli Studi di Palermo Dipartimento di Ingegneria Viale delle Scienze, Ed. 6 Palermo 90128 ItalyIstituto per la Ricerca e l'Innovazione Biomedica Consiglio Nazionale delle Ricerche Palermo 90146 ItalyIstituto per la Ricerca e l'Innovazione Biomedica Consiglio Nazionale delle Ricerche Palermo 90146 ItalyUniversità degli Studi di Palermo Dipartimento di Ingegneria Viale delle Scienze, Ed. 6 Palermo 90128 ItalyAbstract A three‐step electrochemical process is developed to grow a coating on Ti6Al4V alloy for biomedical applications aimed to enhance its bioactivity. The coating is composed by a porous titanium oxide filled with Ag, alginic acid, and hydroxyapatite to provide antibacterial properties and, at the same time, osteointegration capability. Anodized and treated with the electrochemical process samples are characterized by Scanning Electron Microscopy (SEM), Energy‐Dispersive X‐ray Spectroscopy (EDX), X‐Ray Diffraction, and Raman Spectroscopy to have information about morphology and composition soon after the fabrication and after immersion in Hanks’ solution. Bioactivity of the samples is also proved by electrochemical tests through Electrochemical Impedance Spectroscopy (EIS) measurements. Antibacterial properties, cytocompatibility and hemocompatibility of the samples are successfully demonstrated by in vitro tests.https://doi.org/10.1002/admi.202201725Agalginateantibacterial activitybioactivityhydroxyapatiteTi alloys |
| spellingShingle | Davide Pupillo Andrea Zaffora Francesco Di Franco Pasquale Picone Domenico Nuzzo Monica Santamaria Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing Advanced Materials Interfaces Ag alginate antibacterial activity bioactivity hydroxyapatite Ti alloys |
| title | Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing |
| title_full | Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing |
| title_fullStr | Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing |
| title_full_unstemmed | Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing |
| title_short | Enhancing Biocompatibility and Antibacterial Activity of Ti6Al4V by Entrapping Ag and Hydroxyapatite Inside Alginate Filled Pores of TiO2 Layer Grown by Spark Anodizing |
| title_sort | enhancing biocompatibility and antibacterial activity of ti6al4v by entrapping ag and hydroxyapatite inside alginate filled pores of tio2 layer grown by spark anodizing |
| topic | Ag alginate antibacterial activity bioactivity hydroxyapatite Ti alloys |
| url | https://doi.org/10.1002/admi.202201725 |
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