Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats
Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats. Mat...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2016-12-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-321-en.html |
| _version_ | 1828499271004979200 |
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| author | Mania Roozbayani Maghsoud Peeri Hamid Agha-Alinejad Mohammad Ali Azarbayjani |
| author_facet | Mania Roozbayani Maghsoud Peeri Hamid Agha-Alinejad Mohammad Ali Azarbayjani |
| author_sort | Mania Roozbayani |
| collection | DOAJ |
| description | Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats. |
| first_indexed | 2024-12-11T13:21:43Z |
| format | Article |
| id | doaj.art-7a7165f79f8e45d19166842ac0a22e81 |
| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-12-11T13:21:43Z |
| publishDate | 2016-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-7a7165f79f8e45d19166842ac0a22e812022-12-22T01:05:47ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502016-12-0184183190Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male RatsMania Roozbayani0Maghsoud Peeri1Hamid Agha-Alinejad2Mohammad Ali Azarbayjani3 Coach of Exercise Physiology, Department of Exercise Physiology, Boroujerd, Islamic Azad University, Boroujerd, Iran. Professor of Exercise Physiology, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Associate Professor of Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. Professor of Exercise Physiology, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats. Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups. Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027). Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.http://ijdo.ssu.ac.ir/article-1-321-en.htmlHigh intensity interval trainingContinues aerobic trainingDiabetic ratsMIR29ACollagen I |
| spellingShingle | Mania Roozbayani Maghsoud Peeri Hamid Agha-Alinejad Mohammad Ali Azarbayjani Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats Iranian Journal of Diabetes and Obesity High intensity interval training Continues aerobic training Diabetic rats MIR29A Collagen I |
| title | Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats |
| title_full | Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats |
| title_fullStr | Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats |
| title_full_unstemmed | Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats |
| title_short | Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats |
| title_sort | type of aerobic training effect on cardiac muscles mir29a and collagen i gene expression in diabetic male rats |
| topic | High intensity interval training Continues aerobic training Diabetic rats MIR29A Collagen I |
| url | http://ijdo.ssu.ac.ir/article-1-321-en.html |
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