Functional MRI in the investigation of blast-related traumatic brain injury
This review focuses on the application of functional magnetic resonance imaging (fMRI) to the investigation of blast-related traumatic brain injury (bTBI). Relatively little is known about the exact mechanisms of neurophysiological injury and pathological and functional sequelae of bTBI. Furthermore...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00016/full |
| _version_ | 1818965060429545472 |
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| author | John L Graner John L Graner Terrence R Oakes Terrence R Oakes Louis M French Louis M French Louis M French Gerard eRiedy Gerard eRiedy |
| author_facet | John L Graner John L Graner Terrence R Oakes Terrence R Oakes Louis M French Louis M French Louis M French Gerard eRiedy Gerard eRiedy |
| author_sort | John L Graner |
| collection | DOAJ |
| description | This review focuses on the application of functional magnetic resonance imaging (fMRI) to the investigation of blast-related traumatic brain injury (bTBI). Relatively little is known about the exact mechanisms of neurophysiological injury and pathological and functional sequelae of bTBI. Furthermore, in mild bTBI, standard anatomical imaging techniques (MRI and CT) generally fail to show focal lesions and most of the symptoms present as subjective clinical functional deficits. Therefore, an objective test of brain functionality has great potential to aid in patient diagnosis and provide a sensitive measurement to monitor disease progression and treatment. The goal of this review is to highlight the relevant body of blast-related TBI literature and present suggestions and considerations in the development of fMRI studies for the investigation of bTBI. The review begins with a summary of recent bTBI publications followed by discussions of various elements of blast-related injury. Brief reviews of some fMRI techniques that focus on mental processes commonly disrupted by bTBI, including working memory, selective attention, and emotional processing, are presented in addition to a brief review of resting state fMRI. Potential strengths and weaknesses of these approaches as regards bTBI are discussed. Finally, this review presents considerations that must be made when designing fMRI studies for bTBI populations, given the heterogeneous nature of bTBI and its high rate of comorbidity with other physical and psychological injuries. |
| first_indexed | 2024-12-20T13:11:00Z |
| format | Article |
| id | doaj.art-7a71a3794298424cb1960fb26ed351ed |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T13:11:00Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-7a71a3794298424cb1960fb26ed351ed2022-12-21T19:39:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952013-03-01410.3389/fneur.2013.0001639057Functional MRI in the investigation of blast-related traumatic brain injuryJohn L Graner0John L Graner1Terrence R Oakes2Terrence R Oakes3Louis M French4Louis M French5Louis M French6Gerard eRiedy7Gerard eRiedy8National Intrepid Center of Excellence, Walter Reed National Military Medical CenterNational Capital Neuroimaging Consortium, Uniformed Services University of the Health SciencesNational Intrepid Center of Excellence, Walter Reed National Military Medical CenterNational Capital Neuroimaging Consortium, Uniformed Services University of the Health SciencesWalter Reed National Military Medical CenterCenter for Neuroscience and Regenerative MedicineDefense and Veterans Brain Injury Center, Walter Reed National Military Medical CenterNational Intrepid Center of Excellence, Walter Reed National Military Medical CenterNational Capital Neuroimaging Consortium, Uniformed Services University of the Health SciencesThis review focuses on the application of functional magnetic resonance imaging (fMRI) to the investigation of blast-related traumatic brain injury (bTBI). Relatively little is known about the exact mechanisms of neurophysiological injury and pathological and functional sequelae of bTBI. Furthermore, in mild bTBI, standard anatomical imaging techniques (MRI and CT) generally fail to show focal lesions and most of the symptoms present as subjective clinical functional deficits. Therefore, an objective test of brain functionality has great potential to aid in patient diagnosis and provide a sensitive measurement to monitor disease progression and treatment. The goal of this review is to highlight the relevant body of blast-related TBI literature and present suggestions and considerations in the development of fMRI studies for the investigation of bTBI. The review begins with a summary of recent bTBI publications followed by discussions of various elements of blast-related injury. Brief reviews of some fMRI techniques that focus on mental processes commonly disrupted by bTBI, including working memory, selective attention, and emotional processing, are presented in addition to a brief review of resting state fMRI. Potential strengths and weaknesses of these approaches as regards bTBI are discussed. Finally, this review presents considerations that must be made when designing fMRI studies for bTBI populations, given the heterogeneous nature of bTBI and its high rate of comorbidity with other physical and psychological injuries.http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00016/fullBlast InjuriesTraumatic Brain Injuryreviewfunctional magnetic resonance imaging (fMRI)military injury |
| spellingShingle | John L Graner John L Graner Terrence R Oakes Terrence R Oakes Louis M French Louis M French Louis M French Gerard eRiedy Gerard eRiedy Functional MRI in the investigation of blast-related traumatic brain injury Frontiers in Neurology Blast Injuries Traumatic Brain Injury review functional magnetic resonance imaging (fMRI) military injury |
| title | Functional MRI in the investigation of blast-related traumatic brain injury |
| title_full | Functional MRI in the investigation of blast-related traumatic brain injury |
| title_fullStr | Functional MRI in the investigation of blast-related traumatic brain injury |
| title_full_unstemmed | Functional MRI in the investigation of blast-related traumatic brain injury |
| title_short | Functional MRI in the investigation of blast-related traumatic brain injury |
| title_sort | functional mri in the investigation of blast related traumatic brain injury |
| topic | Blast Injuries Traumatic Brain Injury review functional magnetic resonance imaging (fMRI) military injury |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00016/full |
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