Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study
Abstract Background Laparoscopic surgery for T4 colon cancer may be safe in selected patients. We hypothesized that small tumor size might preoperatively predict a good laparoscopic surgery outcome. Herein, we compared the clinicopathologic and oncologic outcomes of laparoscopic and open surgery in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-020-02074-5 |
| _version_ | 1818408071202865152 |
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| author | Sung Sil Park Joon Sang Lee Hyoung-Chul Park Sung Chan Park Dae Kyung Sohn Jae Hwan Oh Kyung Su Han Dong-Won Lee Dong-Eun Lee Sung-Bum Kang Kyu Joo Park Seung-Yong Jeong on behalf of the Seoul Colorectal Research Group (SECOG) |
| author_facet | Sung Sil Park Joon Sang Lee Hyoung-Chul Park Sung Chan Park Dae Kyung Sohn Jae Hwan Oh Kyung Su Han Dong-Won Lee Dong-Eun Lee Sung-Bum Kang Kyu Joo Park Seung-Yong Jeong on behalf of the Seoul Colorectal Research Group (SECOG) |
| author_sort | Sung Sil Park |
| collection | DOAJ |
| description | Abstract Background Laparoscopic surgery for T4 colon cancer may be safe in selected patients. We hypothesized that small tumor size might preoperatively predict a good laparoscopic surgery outcome. Herein, we compared the clinicopathologic and oncologic outcomes of laparoscopic and open surgery in small T4 colon cancer. Methods In a retrospective multicenter study, we reviewed the data of 449 patients, including 117 patients with tumors ≤ 4.0 cm who underwent surgery for T4 colon cancer between January 2014 and December 2017. We compared the clinicopathologic and 3-year oncologic outcomes between the laparoscopic and open groups. Survival curves were estimated using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model. A p < 0.05 was considered statistically significant. Results Blood loss, length of hospital stay, and postoperative morbidity were lower in the laparoscopic group than in the open group (median [range], 50 [0–700] vs. 100 [0–4000] mL, p < 0.001; 8 vs. 10 days, p < 0.001; and 18.0 vs. 29.5%, p = 0.005, respectively). There were no intergroup differences in 3-year overall survival or disease-free survival (86.6 vs. 83.2%, p = 0.180, and 71.7 vs. 75.1%, p = 0.720, respectively). Among patients with tumor size ≤ 4.0 cm, blood loss was significantly lower in the laparoscopic group than in the open group (median [range], 50 [0–530] vs. 50 [0–1000] mL, p = 0.003). Despite no statistical difference observed in the 3-year overall survival rate (83.3 vs. 78.7%, p = 0.538), the laparoscopic group had a significantly higher 3-year disease-free survival rate (79.2 vs. 53.2%, p = 0.012). Conclusions Laparoscopic surgery showed similar outcomes to open surgery in T4 colon cancer patients and may have favorable short-term oncologic outcomes in patients with tumors ≤ 4.0 cm. |
| first_indexed | 2024-12-14T09:37:54Z |
| format | Article |
| id | doaj.art-7a71b48957634a7db023a4c0ade2c0df |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-14T09:37:54Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-7a71b48957634a7db023a4c0ade2c0df2022-12-21T23:07:52ZengBMCWorld Journal of Surgical Oncology1477-78192020-11-0118111010.1186/s12957-020-02074-5Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative studySung Sil Park0Joon Sang Lee1Hyoung-Chul Park2Sung Chan Park3Dae Kyung Sohn4Jae Hwan Oh5Kyung Su Han6Dong-Won Lee7Dong-Eun Lee8Sung-Bum Kang9Kyu Joo Park10Seung-Yong Jeong11on behalf of the Seoul Colorectal Research Group (SECOG)Center for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterCenter for Colorectal Cancer, National Cancer CenterBiostatistics Collaboration Team, Research Institute and Hospital, National Cancer CenterDepartment of Surgery, Seoul National University Bundang HospitalDepartment of Surgery, Seoul National University College of MedicineDepartment of Surgery, Seoul National University College of MedicineAbstract Background Laparoscopic surgery for T4 colon cancer may be safe in selected patients. We hypothesized that small tumor size might preoperatively predict a good laparoscopic surgery outcome. Herein, we compared the clinicopathologic and oncologic outcomes of laparoscopic and open surgery in small T4 colon cancer. Methods In a retrospective multicenter study, we reviewed the data of 449 patients, including 117 patients with tumors ≤ 4.0 cm who underwent surgery for T4 colon cancer between January 2014 and December 2017. We compared the clinicopathologic and 3-year oncologic outcomes between the laparoscopic and open groups. Survival curves were estimated using the Kaplan–Meier method and compared using the log-rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model. A p < 0.05 was considered statistically significant. Results Blood loss, length of hospital stay, and postoperative morbidity were lower in the laparoscopic group than in the open group (median [range], 50 [0–700] vs. 100 [0–4000] mL, p < 0.001; 8 vs. 10 days, p < 0.001; and 18.0 vs. 29.5%, p = 0.005, respectively). There were no intergroup differences in 3-year overall survival or disease-free survival (86.6 vs. 83.2%, p = 0.180, and 71.7 vs. 75.1%, p = 0.720, respectively). Among patients with tumor size ≤ 4.0 cm, blood loss was significantly lower in the laparoscopic group than in the open group (median [range], 50 [0–530] vs. 50 [0–1000] mL, p = 0.003). Despite no statistical difference observed in the 3-year overall survival rate (83.3 vs. 78.7%, p = 0.538), the laparoscopic group had a significantly higher 3-year disease-free survival rate (79.2 vs. 53.2%, p = 0.012). Conclusions Laparoscopic surgery showed similar outcomes to open surgery in T4 colon cancer patients and may have favorable short-term oncologic outcomes in patients with tumors ≤ 4.0 cm.http://link.springer.com/article/10.1186/s12957-020-02074-5Colon cancerLaparoscopyOpen surgeryT4 cancerTumor size |
| spellingShingle | Sung Sil Park Joon Sang Lee Hyoung-Chul Park Sung Chan Park Dae Kyung Sohn Jae Hwan Oh Kyung Su Han Dong-Won Lee Dong-Eun Lee Sung-Bum Kang Kyu Joo Park Seung-Yong Jeong on behalf of the Seoul Colorectal Research Group (SECOG) Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study World Journal of Surgical Oncology Colon cancer Laparoscopy Open surgery T4 cancer Tumor size |
| title | Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study |
| title_full | Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study |
| title_fullStr | Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study |
| title_full_unstemmed | Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study |
| title_short | Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study |
| title_sort | favorable short term oncologic outcomes following laparoscopic surgery for small t4 colon cancer a multicenter comparative study |
| topic | Colon cancer Laparoscopy Open surgery T4 cancer Tumor size |
| url | http://link.springer.com/article/10.1186/s12957-020-02074-5 |
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