Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study
Purpose: To evaluate the role of strain elastography (SE) in reclassification of indeterminate breast lesions placed under BIRADS 3 and 4 categories by conventional ultrasound (US) parameters so as to recourse biopsy only for suspicious stiffer lesions. Methods: 113 breast lesions in 100 women assig...
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| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-10-01
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| Series: | Indian Journal of Radiology and Imaging |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_425_19 |
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| author | Dimpi Sinha Nischal G Kundaragi Sukrity Sharma Sudhir K Kale |
| author_facet | Dimpi Sinha Nischal G Kundaragi Sukrity Sharma Sudhir K Kale |
| author_sort | Dimpi Sinha |
| collection | DOAJ |
| description | Purpose: To evaluate the role of strain elastography (SE) in reclassification of indeterminate breast lesions placed under BIRADS 3 and 4 categories by conventional ultrasound (US) parameters so as to recourse biopsy only for suspicious stiffer lesions. Methods: 113 breast lesions in 100 women assigned as BIRADS category 3 and 4 on US parameters were prospectively evaluated by SE followed by histo-pathological examination. Strain ratio (SR) and Elastography Score (ES) were determined for each lesion. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each modality and diagnostic performance were compared. The best cut-off point was calculated for each of the elastography parameter using the receiver operator curve analysis (ROC). Results: Out of the 113 lesions, 40 were malignant (35.4’) and 73 were benign (64.6’). A statistically significant difference was observed in the AUC for ES and conventional US: 0.98 vs 0.90 (Difference = 0.08, P = 0.02). Elastography parameters were more specific as compared to US (ES-94.5 & SR-93.2’ vs 63’, P < 0.05) with high NPV. SE performed better in BIRADS 4 category lesions. On the basis of elastography parameters, 85’ of BIRADS 4 category lesions were correctly predicted as benign with overall sensitivity, specificity and diagnostic accuracy of elastography being 97’, 84.6’ and 91.9’. Among BIRADS 3 category lesions, 97’ were correctly predicted as benign and 50’ lesions were correctly predicted as malignant with a sensitivity of 50’, specificity of 97.8’ and diagnostic accuracy of 94’. Conclusion: Strain elastography is a useful adjunct to conventional ultrasonography for the assessment of indeterminate breast lesions and may help in avoiding unnecessary follow ups and biopsies. Elastography score is a better parameter as compared to strain ratio. |
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| institution | Directory Open Access Journal |
| issn | 0971-3026 1998-3808 |
| language | English |
| last_indexed | 2024-12-17T06:58:53Z |
| publishDate | 2020-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Radiology and Imaging |
| spelling | doaj.art-7a71eda5fb894ec5bb67f98dc43e03d02022-12-21T21:59:20ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082020-10-01300449349910.4103/ijri.IJRI_425_19Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective studyDimpi Sinha0Nischal G Kundaragi1Sukrity Sharma2Sudhir K Kale3Departments of Radiology, Aster CMI Hospital Bangalore, Karnataka, IndiaDepartments of Interventional Radiology Aster CMI Hospital Bangalore, Karnataka, IndiaDepartments of Radiology, Aster CMI Hospital Bangalore, Karnataka, IndiaDepartments of Radiology, Aster CMI Hospital Bangalore, Karnataka, IndiaPurpose: To evaluate the role of strain elastography (SE) in reclassification of indeterminate breast lesions placed under BIRADS 3 and 4 categories by conventional ultrasound (US) parameters so as to recourse biopsy only for suspicious stiffer lesions. Methods: 113 breast lesions in 100 women assigned as BIRADS category 3 and 4 on US parameters were prospectively evaluated by SE followed by histo-pathological examination. Strain ratio (SR) and Elastography Score (ES) were determined for each lesion. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each modality and diagnostic performance were compared. The best cut-off point was calculated for each of the elastography parameter using the receiver operator curve analysis (ROC). Results: Out of the 113 lesions, 40 were malignant (35.4’) and 73 were benign (64.6’). A statistically significant difference was observed in the AUC for ES and conventional US: 0.98 vs 0.90 (Difference = 0.08, P = 0.02). Elastography parameters were more specific as compared to US (ES-94.5 & SR-93.2’ vs 63’, P < 0.05) with high NPV. SE performed better in BIRADS 4 category lesions. On the basis of elastography parameters, 85’ of BIRADS 4 category lesions were correctly predicted as benign with overall sensitivity, specificity and diagnostic accuracy of elastography being 97’, 84.6’ and 91.9’. Among BIRADS 3 category lesions, 97’ were correctly predicted as benign and 50’ lesions were correctly predicted as malignant with a sensitivity of 50’, specificity of 97.8’ and diagnostic accuracy of 94’. Conclusion: Strain elastography is a useful adjunct to conventional ultrasonography for the assessment of indeterminate breast lesions and may help in avoiding unnecessary follow ups and biopsies. Elastography score is a better parameter as compared to strain ratio.http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_425_19breast cancerelasticity scorestrain elastographystrain ratioultrasonography |
| spellingShingle | Dimpi Sinha Nischal G Kundaragi Sukrity Sharma Sudhir K Kale Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study Indian Journal of Radiology and Imaging breast cancer elasticity score strain elastography strain ratio ultrasonography |
| title | Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study |
| title_full | Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study |
| title_fullStr | Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study |
| title_full_unstemmed | Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study |
| title_short | Can strain elastography be used in reclassification of indeterminate breast lesions in BIRADS lexicon?: A prospective study |
| title_sort | can strain elastography be used in reclassification of indeterminate breast lesions in birads lexicon a prospective study |
| topic | breast cancer elasticity score strain elastography strain ratio ultrasonography |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_425_19 |
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