Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria
Methylmalonicaciduia(MMA)accompanied with homocystinuria is a rare autosomal-recessive with congenital metabolic disorder of Vitamin B12. There are three subtypes, cblC, cblD, cblF, in which cblC is the most common one. The diagnostic tests are tandem mass spectrometry and gas chromatography-mass sp...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-12-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2015/12/201512017.pdf |
| _version_ | 1811305275342192640 |
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| author | Qiu-Jing Huang Qi Zhang Jie Peng Yi-An Li Pei-Quan Zhao |
| author_facet | Qiu-Jing Huang Qi Zhang Jie Peng Yi-An Li Pei-Quan Zhao |
| author_sort | Qiu-Jing Huang |
| collection | DOAJ |
| description | Methylmalonicaciduia(MMA)accompanied with homocystinuria is a rare autosomal-recessive with congenital metabolic disorder of Vitamin B12. There are three subtypes, cblC, cblD, cblF, in which cblC is the most common one. The diagnostic tests are tandem mass spectrometry and gas chromatography-mass spectrometry. Tests for activity of enzyme in fibroblasts from skin, complementary assay and genetic analysis can be used to make the subtype clear. Early-onset patients, defined by onset of symptoms before the age of 1 year, may have severe ocular involvement, including visual loss, nystagmus, strabismus, retinopathy, maculopathy, optic atrophy, abnormal electroretinography. Late-onset patients, defined by onset of symptoms after the age of 4 year, rarely have ocular manifestations. The pathogenesis of the ophthalmic symptoms may be related to the high level of homocystine, oxidative stress and the abnormal development of nervous systems. The treatment for MMA accompanied with homocystinuria is mostly symptomatic based. Ophthalmic treatment is limited. Early supplement of methionine,GSH or other antioxidants may be helpful for retinopathy. There is no standard ophthalmological examination for those patients in China. It is critical to set up inter-departmental cooperation and early stage examination for the treatments and outcomes of the patients. |
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| format | Article |
| id | doaj.art-7a73f17ca705491f9bbf35b8ae7e3942 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-04-13T08:22:38Z |
| publishDate | 2015-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7a73f17ca705491f9bbf35b8ae7e39422022-12-22T02:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232015-12-0115122090209310.3980/j.issn.1672-5123.2015.12.17Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuriaQiu-Jing Huang0Qi Zhang1Jie Peng2Yi-An Li3Pei-Quan Zhao4Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200023,ChinaDepartment of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200023,ChinaDepartment of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200023,ChinaDepartment of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200023,ChinaDepartment of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200023,ChinaMethylmalonicaciduia(MMA)accompanied with homocystinuria is a rare autosomal-recessive with congenital metabolic disorder of Vitamin B12. There are three subtypes, cblC, cblD, cblF, in which cblC is the most common one. The diagnostic tests are tandem mass spectrometry and gas chromatography-mass spectrometry. Tests for activity of enzyme in fibroblasts from skin, complementary assay and genetic analysis can be used to make the subtype clear. Early-onset patients, defined by onset of symptoms before the age of 1 year, may have severe ocular involvement, including visual loss, nystagmus, strabismus, retinopathy, maculopathy, optic atrophy, abnormal electroretinography. Late-onset patients, defined by onset of symptoms after the age of 4 year, rarely have ocular manifestations. The pathogenesis of the ophthalmic symptoms may be related to the high level of homocystine, oxidative stress and the abnormal development of nervous systems. The treatment for MMA accompanied with homocystinuria is mostly symptomatic based. Ophthalmic treatment is limited. Early supplement of methionine,GSH or other antioxidants may be helpful for retinopathy. There is no standard ophthalmological examination for those patients in China. It is critical to set up inter-departmental cooperation and early stage examination for the treatments and outcomes of the patients.http://ies.ijo.cn/cn_publish/2015/12/201512017.pdfmethylmalonic aciduriahomocystinuriaretinopathynystagmusstrabismus |
| spellingShingle | Qiu-Jing Huang Qi Zhang Jie Peng Yi-An Li Pei-Quan Zhao Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria Guoji Yanke Zazhi methylmalonic aciduria homocystinuria retinopathy nystagmus strabismus |
| title | Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| title_full | Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| title_fullStr | Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| title_full_unstemmed | Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| title_short | Ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| title_sort | ophthalmic manifestations of methylmalonic aciduria accompanied with homocystinuria |
| topic | methylmalonic aciduria homocystinuria retinopathy nystagmus strabismus |
| url | http://ies.ijo.cn/cn_publish/2015/12/201512017.pdf |
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