Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus.

Type I interferon-mediated skewing of the serotonin synthesis is associated with severe disease in systemic lupus erythematosus.

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study...

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Bibliographic Details
Main Authors: Christian Lood, Helena Tydén, Birgitta Gullstrand, Cecilia Klint, Christina Wenglén, Christoffer T Nielsen, Niels H H Heegaard, Andreas Jönsen, Robin Kahn, Anders A Bengtsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4405357?pdf=render

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