Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review
T-cell large granular lymphocyte (T-LGL) leukemia is a rare and indolent clonal disorder of LGLs, associated with rheumatoid arthritis and neutropenia. The authors present a case of a 62-year-old male with rheumatoid arthritis (RA) who was diagnosed with T-LGL leukemia, with predominant neutropenia,...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2022-07-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661341722720026 |
| _version_ | 1828822972998090752 |
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| author | Young Min Cho Erik W. Anderson Sara Guevara Santiago J. Miyara Aqsa Iqbal Judith Aronsohn Ernesto P. Molmenti James M. Mumford Barbara Keber Farideh Zonouzi-Zadeh Yousoun Ha Petros G. Nikolinakos Brent Flickinger |
| author_facet | Young Min Cho Erik W. Anderson Sara Guevara Santiago J. Miyara Aqsa Iqbal Judith Aronsohn Ernesto P. Molmenti James M. Mumford Barbara Keber Farideh Zonouzi-Zadeh Yousoun Ha Petros G. Nikolinakos Brent Flickinger |
| author_sort | Young Min Cho |
| collection | DOAJ |
| description | T-cell large granular lymphocyte (T-LGL) leukemia is a rare and indolent clonal disorder of LGLs, associated with rheumatoid arthritis and neutropenia. The authors present a case of a 62-year-old male with rheumatoid arthritis (RA) who was diagnosed with T-LGL leukemia, with predominant neutropenia, and a poor response to conventional treatment. Subsequently, tofacitinib (a Janus Kinase 1 and 3 inhibitor, [JAK1/3 inhibitor]) resulted in improvement of the patient’s RA symptoms and temporary improvement of the neutropenia. Ultimately, upadacitinib (a specific JAK1 inhibitor) resulted in further improvement of the neutropenia and control of his RA. To the best of our knowledge, this is the first case report of coexisting RA and LGL leukemia that was treated with upadacitinib and showed clinical improvement. |
| first_indexed | 2024-12-12T13:26:03Z |
| format | Article |
| id | doaj.art-7a764eca4f9a48dbbd511e76ba0c7355 |
| institution | Directory Open Access Journal |
| issn | 2661-3417 2661-3425 |
| language | English |
| last_indexed | 2024-12-12T13:26:03Z |
| publishDate | 2022-07-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj.art-7a764eca4f9a48dbbd511e76ba0c73552022-12-22T00:23:10ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252022-07-012201223010.1142/S2661341722720026Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative ReviewYoung Min Cho0Erik W. Anderson1Sara Guevara2Santiago J. Miyara3Aqsa Iqbal4Judith Aronsohn5Ernesto P. Molmenti6James M. Mumford7Barbara Keber8Farideh Zonouzi-Zadeh9Yousoun Ha10Petros G. Nikolinakos11Brent Flickinger12Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GeorgiaFeinstein Institutes for Medical Research, Manhasset, New York, USADonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USAFeinstein Institutes for Medical Research, Manhasset, New York, USADepartment of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GeorgiaDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USADonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USADonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USADonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USADonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USADepartment of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GeorgiaDepartment of Hematology and Oncology, Piedmont Athens Regional Medical Center, Athens, GeorgiaDepartment of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GeorgiaT-cell large granular lymphocyte (T-LGL) leukemia is a rare and indolent clonal disorder of LGLs, associated with rheumatoid arthritis and neutropenia. The authors present a case of a 62-year-old male with rheumatoid arthritis (RA) who was diagnosed with T-LGL leukemia, with predominant neutropenia, and a poor response to conventional treatment. Subsequently, tofacitinib (a Janus Kinase 1 and 3 inhibitor, [JAK1/3 inhibitor]) resulted in improvement of the patient’s RA symptoms and temporary improvement of the neutropenia. Ultimately, upadacitinib (a specific JAK1 inhibitor) resulted in further improvement of the neutropenia and control of his RA. To the best of our knowledge, this is the first case report of coexisting RA and LGL leukemia that was treated with upadacitinib and showed clinical improvement.https://www.worldscientific.com/doi/10.1142/S2661341722720026Large Granular Lymphocytic LeukemiaJanus KinaseRheumatoid ArthritisNovel Treatment |
| spellingShingle | Young Min Cho Erik W. Anderson Sara Guevara Santiago J. Miyara Aqsa Iqbal Judith Aronsohn Ernesto P. Molmenti James M. Mumford Barbara Keber Farideh Zonouzi-Zadeh Yousoun Ha Petros G. Nikolinakos Brent Flickinger Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review Journal of Clinical Rheumatology and Immunology Large Granular Lymphocytic Leukemia Janus Kinase Rheumatoid Arthritis Novel Treatment |
| title | Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review |
| title_full | Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review |
| title_fullStr | Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review |
| title_full_unstemmed | Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review |
| title_short | Upadacitinib as Novel Treatment for Rheumatoid Arthritis with T-Cell Granular Lymphocytic Leukemia: A Case Report and Narrative Review |
| title_sort | upadacitinib as novel treatment for rheumatoid arthritis with t cell granular lymphocytic leukemia a case report and narrative review |
| topic | Large Granular Lymphocytic Leukemia Janus Kinase Rheumatoid Arthritis Novel Treatment |
| url | https://www.worldscientific.com/doi/10.1142/S2661341722720026 |
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