Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids
By reduction of available [(1-aryl-5-formylimidazole-4-il)thio] acetic acids with sodium borohydrideinaqueous solution in presence of 20% solution of sodium hydroxide [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids were synthesized. Their structure was proved by results of measurements of IR-...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2014-04-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/25447/22939 |
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| author | V. O. Chornous A. O. Palamar I. M. Yaremiy N. D. Yakovychuk M. V. Vovk |
| author_facet | V. O. Chornous A. O. Palamar I. M. Yaremiy N. D. Yakovychuk M. V. Vovk |
| author_sort | V. O. Chornous |
| collection | DOAJ |
| description | By reduction of available [(1-aryl-5-formylimidazole-4-il)thio] acetic acids with sodium borohydrideinaqueous solution in presence of 20% solution of sodium hydroxide [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids were synthesized. Their structure was proved by results of measurements of IR-, NMR 1H and chromatography-mass pectra. Primary screening of antioxidant properties showed that in in vitro experiments all of the studied compounds are active in range of concentrations between10-1-10-3mole/l, and the highest antioxidant effect is shown by {[5-hydroxymethyl-1-(3-methylphenyl)-1Н-imidazole-4-il]thio} acetic acid in concentration 10-3 М, which is credibly the same as the effect of thiotriazolin in the same concentration. It was found that the synthesized compounds show moderate antimicrobial and antifungal effect. |
| first_indexed | 2024-12-12T09:29:09Z |
| format | Article |
| id | doaj.art-7a779c12fdde489f9ab7a98885a98e76 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-12T09:29:09Z |
| publishDate | 2014-04-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-7a779c12fdde489f9ab7a98885a98e762022-12-22T00:28:55ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-04-01210310610.14739/2310-1210.2014.2.25447Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acidsV. O. ChornousA. O. PalamarI. M. YaremiyN. D. YakovychukM. V. VovkBy reduction of available [(1-aryl-5-formylimidazole-4-il)thio] acetic acids with sodium borohydrideinaqueous solution in presence of 20% solution of sodium hydroxide [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids were synthesized. Their structure was proved by results of measurements of IR-, NMR 1H and chromatography-mass pectra. Primary screening of antioxidant properties showed that in in vitro experiments all of the studied compounds are active in range of concentrations between10-1-10-3mole/l, and the highest antioxidant effect is shown by {[5-hydroxymethyl-1-(3-methylphenyl)-1Н-imidazole-4-il]thio} acetic acid in concentration 10-3 М, which is credibly the same as the effect of thiotriazolin in the same concentration. It was found that the synthesized compounds show moderate antimicrobial and antifungal effect.http://zmj.zsmu.edu.ua/article/view/25447/22939[(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acidsreductionantioxidantantimicrobial and antifungal activity |
| spellingShingle | V. O. Chornous A. O. Palamar I. M. Yaremiy N. D. Yakovychuk M. V. Vovk Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids Zaporožskij Medicinskij Žurnal [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids reduction antioxidant antimicrobial and antifungal activity |
| title | Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids |
| title_full | Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids |
| title_fullStr | Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids |
| title_full_unstemmed | Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids |
| title_short | Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids |
| title_sort | synthesis and evaluation of antioxidant antimicrobial and antifungal effect of 5 hydroxymethyl 1h imidazole 4 il thio acetic acids |
| topic | [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids reduction antioxidant antimicrobial and antifungal activity |
| url | http://zmj.zsmu.edu.ua/article/view/25447/22939 |
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