Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review
Background:. Functional recovery after peripheral nerve injury is often suboptimal despite the intrinsic permissive growth environment of the peripheral nervous system. The objective of this systematic review is to explore the use of electrical stimulation (ES) for peripheral nerve regeneration. Met...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2022-03-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004115 |
| _version_ | 1818307906276163584 |
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| author | Rawan ElAbd, MD Abdulaziz Alabdulkarim, MD, FRCS(C) Salman AlSabah, MD, FRCS (C), FACS Jessica Hazan, MD Becher Alhalabi, MD FRCS(C) Stephanie Thibaudeau, MD, FRCS(C) |
| author_facet | Rawan ElAbd, MD Abdulaziz Alabdulkarim, MD, FRCS(C) Salman AlSabah, MD, FRCS (C), FACS Jessica Hazan, MD Becher Alhalabi, MD FRCS(C) Stephanie Thibaudeau, MD, FRCS(C) |
| author_sort | Rawan ElAbd, MD |
| collection | DOAJ |
| description | Background:. Functional recovery after peripheral nerve injury is often suboptimal despite the intrinsic permissive growth environment of the peripheral nervous system. The objective of this systematic review is to explore the use of electrical stimulation (ES) for peripheral nerve regeneration.
Methods:. A systematic literature search was conducted from inception to March 2, 2021 to retrieve articles on ES for peripheral nerve regeneration using the PubMed, Ovid MEDLINE, and Embase databases. Primary outcome measures included objective measures of motor and sensory nerve function.
Results:. Four randomized control trials, two case reports, and three case series that addressed the aims were identified. The stimulation parameters varied greatly between studies, without an apparent commonality for a given electrical conduit. Outcomes measured included motor (n = 8) and sensory (n = 7) modalities (cold detection, static two-point discrimination, tactile discrimination, and pressure detection), nerve-specific muscle function and bulk, and electromyography (EMG) motor and sensory terminal latency. Different parameters for measurement were utilized and improvement was observed across the studies compared with controls (n = 4) or pre-intervention measurements (n = 5). One randomized control trial reported no benefit of ES and attributed their findings to their stimulation protocol. Complications were documented in three patients only and included wire remnant removal, skin pigmentation, and bone formation.
Conclusions:. ES in peripheral nerve regeneration is beneficial in improving and accelerating recovery. A meta-analysis was not performed due to the heterogeneity, but all studies showed positive findings and minor to no complications. These results provide a primer for further development of delivery methods. |
| first_indexed | 2024-12-13T07:05:49Z |
| format | Article |
| id | doaj.art-7a77d786628a4744834f63be9421d44c |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-12-13T07:05:49Z |
| publishDate | 2022-03-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-7a77d786628a4744834f63be9421d44c2022-12-21T23:55:49ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742022-03-01103e411510.1097/GOX.0000000000004115202203000-00037Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic ReviewRawan ElAbd, MD0Abdulaziz Alabdulkarim, MD, FRCS(C)1Salman AlSabah, MD, FRCS (C), FACS2Jessica Hazan, MD3Becher Alhalabi, MD FRCS(C)4Stephanie Thibaudeau, MD, FRCS(C)5From the * Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait† Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, QC, CanadaFrom the * Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait† Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, QC, Canada† Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, QC, Canada† Division of Plastic and Reconstructive Surgery, McGill University Health Centre, Montreal, QC, CanadaBackground:. Functional recovery after peripheral nerve injury is often suboptimal despite the intrinsic permissive growth environment of the peripheral nervous system. The objective of this systematic review is to explore the use of electrical stimulation (ES) for peripheral nerve regeneration. Methods:. A systematic literature search was conducted from inception to March 2, 2021 to retrieve articles on ES for peripheral nerve regeneration using the PubMed, Ovid MEDLINE, and Embase databases. Primary outcome measures included objective measures of motor and sensory nerve function. Results:. Four randomized control trials, two case reports, and three case series that addressed the aims were identified. The stimulation parameters varied greatly between studies, without an apparent commonality for a given electrical conduit. Outcomes measured included motor (n = 8) and sensory (n = 7) modalities (cold detection, static two-point discrimination, tactile discrimination, and pressure detection), nerve-specific muscle function and bulk, and electromyography (EMG) motor and sensory terminal latency. Different parameters for measurement were utilized and improvement was observed across the studies compared with controls (n = 4) or pre-intervention measurements (n = 5). One randomized control trial reported no benefit of ES and attributed their findings to their stimulation protocol. Complications were documented in three patients only and included wire remnant removal, skin pigmentation, and bone formation. Conclusions:. ES in peripheral nerve regeneration is beneficial in improving and accelerating recovery. A meta-analysis was not performed due to the heterogeneity, but all studies showed positive findings and minor to no complications. These results provide a primer for further development of delivery methods.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004115 |
| spellingShingle | Rawan ElAbd, MD Abdulaziz Alabdulkarim, MD, FRCS(C) Salman AlSabah, MD, FRCS (C), FACS Jessica Hazan, MD Becher Alhalabi, MD FRCS(C) Stephanie Thibaudeau, MD, FRCS(C) Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review Plastic and Reconstructive Surgery, Global Open |
| title | Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review |
| title_full | Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review |
| title_fullStr | Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review |
| title_full_unstemmed | Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review |
| title_short | Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review |
| title_sort | role of electrical stimulation in peripheral nerve regeneration a systematic review |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004115 |
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