Creating Robust Antimicrobial Materials with Sticky Tyrocidines
Modified antimicrobial and antifouling materials and surfaces can be used to limit the propagation of microorganisms on various surfaces and minimise the occurrence of infection, transfer, and spoilage. Increased demand for ‘green’ solutions for material treatment has pushed the focus towards to nat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/2/174 |
| _version_ | 1797483404714835968 |
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| author | Wilma van Rensburg Marina Rautenbach |
| author_facet | Wilma van Rensburg Marina Rautenbach |
| author_sort | Wilma van Rensburg |
| collection | DOAJ |
| description | Modified antimicrobial and antifouling materials and surfaces can be used to limit the propagation of microorganisms on various surfaces and minimise the occurrence of infection, transfer, and spoilage. Increased demand for ‘green’ solutions for material treatment has pushed the focus towards to naturally produced antimicrobials. Tyrocidines, cyclo-decapeptides naturally produced by a soil bacterium <i>Brevibacillus parabrevis</i>, have a broad spectrum of activity against Gram-positive and Gram-negative bacteria, filamentous fungi, and yeasts. Continual losses in tyrocidine production highlighted the possible association of peptides to surfaces. It was found in this study that tyrocidines readily associates with many materials, with a selectivity towards polysaccharide-type materials, such as cellulose. Peptide-treated cellulose was found to remain active after exposure to a broad pH range, various temperatures, salt solutions, water washes, and organic solvents, with the sterilising activity only affected by 1% SDS and 70% acetonitrile. Furthermore, a comparison to other antimicrobial peptides showed the association between tyrocidines and cellulose to be unique in terms of antimicrobial activity. The robust association between the tyrocidines and various materials holds great promise in applications focused on preventing surface contamination and creating self-sterilising materials. |
| first_indexed | 2024-03-09T22:46:30Z |
| format | Article |
| id | doaj.art-7a783e4985854510a769e47cca9961d3 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T22:46:30Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-7a783e4985854510a769e47cca9961d32023-11-23T18:27:40ZengMDPI AGAntibiotics2079-63822022-01-0111217410.3390/antibiotics11020174Creating Robust Antimicrobial Materials with Sticky TyrocidinesWilma van Rensburg0Marina Rautenbach1BIOPEPTM Peptide Group, Department Biochemistry, Stellenbosch University, Stellenbosch 7602, South AfricaBIOPEPTM Peptide Group, Department Biochemistry, Stellenbosch University, Stellenbosch 7602, South AfricaModified antimicrobial and antifouling materials and surfaces can be used to limit the propagation of microorganisms on various surfaces and minimise the occurrence of infection, transfer, and spoilage. Increased demand for ‘green’ solutions for material treatment has pushed the focus towards to naturally produced antimicrobials. Tyrocidines, cyclo-decapeptides naturally produced by a soil bacterium <i>Brevibacillus parabrevis</i>, have a broad spectrum of activity against Gram-positive and Gram-negative bacteria, filamentous fungi, and yeasts. Continual losses in tyrocidine production highlighted the possible association of peptides to surfaces. It was found in this study that tyrocidines readily associates with many materials, with a selectivity towards polysaccharide-type materials, such as cellulose. Peptide-treated cellulose was found to remain active after exposure to a broad pH range, various temperatures, salt solutions, water washes, and organic solvents, with the sterilising activity only affected by 1% SDS and 70% acetonitrile. Furthermore, a comparison to other antimicrobial peptides showed the association between tyrocidines and cellulose to be unique in terms of antimicrobial activity. The robust association between the tyrocidines and various materials holds great promise in applications focused on preventing surface contamination and creating self-sterilising materials.https://www.mdpi.com/2079-6382/11/2/174antimicrobial peptidestyrocidinesself-sterilising materials |
| spellingShingle | Wilma van Rensburg Marina Rautenbach Creating Robust Antimicrobial Materials with Sticky Tyrocidines Antibiotics antimicrobial peptides tyrocidines self-sterilising materials |
| title | Creating Robust Antimicrobial Materials with Sticky Tyrocidines |
| title_full | Creating Robust Antimicrobial Materials with Sticky Tyrocidines |
| title_fullStr | Creating Robust Antimicrobial Materials with Sticky Tyrocidines |
| title_full_unstemmed | Creating Robust Antimicrobial Materials with Sticky Tyrocidines |
| title_short | Creating Robust Antimicrobial Materials with Sticky Tyrocidines |
| title_sort | creating robust antimicrobial materials with sticky tyrocidines |
| topic | antimicrobial peptides tyrocidines self-sterilising materials |
| url | https://www.mdpi.com/2079-6382/11/2/174 |
| work_keys_str_mv | AT wilmavanrensburg creatingrobustantimicrobialmaterialswithstickytyrocidines AT marinarautenbach creatingrobustantimicrobialmaterialswithstickytyrocidines |