Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43

TAR DNA-binding protein 43 (TDP-43) is a predominant component of inclusions in the brains and spines of patients with amyotrophic lateral sclerosis (ALS). The progressive accumulation of inclusions leads to proteinopathy in neurons. We have previously shown that Met1(M1)-linked linear ubiquitin, wh...

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Bibliographic Details
Main Authors: Qiang Zhang, Seigo Terawaki, Daisuke Oikawa, Yoshinori Okina, Yoshinosuke Usuki, Hidefumi Ito, Fuminori Tokunaga
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
ALS
cytoplasmic aggregation
LUBAC
NF-κB
TDP-43
ubiquitin
Online Access:https://www.mdpi.com/2073-4409/11/15/2398

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