Regulation of Glycosylation in Bone Metabolism
Glycosylation plays a crucial role in the maintenance of homeostasis in the body and at the onset of diseases such as inflammation, neurodegeneration, infection, diabetes, and cancer. It is also involved in bone metabolism. <i>N</i>- and <i>O</i>-glycans have been shown to re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/7/3568 |
| _version_ | 1797212576053985280 |
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| author | Kazunori Hamamura Mayu Nagao Koichi Furukawa |
| author_facet | Kazunori Hamamura Mayu Nagao Koichi Furukawa |
| author_sort | Kazunori Hamamura |
| collection | DOAJ |
| description | Glycosylation plays a crucial role in the maintenance of homeostasis in the body and at the onset of diseases such as inflammation, neurodegeneration, infection, diabetes, and cancer. It is also involved in bone metabolism. <i>N</i>- and <i>O</i>-glycans have been shown to regulate osteoblast and osteoclast differentiation. We recently demonstrated that ganglio-series and globo-series glycosphingolipids were essential for regulating the proliferation and differentiation of osteoblasts and osteoclasts in glycosyltransferase-knockout mice. Herein, we reviewed the importance of the regulation of bone metabolism by glycoconjugates, such as glycolipids and glycoproteins, including our recent results. |
| first_indexed | 2024-04-24T10:44:34Z |
| format | Article |
| id | doaj.art-7a7d4588aa7a4b3f8a96092bc0e9a801 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T10:44:34Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7a7d4588aa7a4b3f8a96092bc0e9a8012024-04-12T13:19:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01257356810.3390/ijms25073568Regulation of Glycosylation in Bone MetabolismKazunori Hamamura0Mayu Nagao1Koichi Furukawa2Department of Pharmacology, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, JapanDepartment of Pharmacology, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, JapanDepartment of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai 487-8501, Aichi, JapanGlycosylation plays a crucial role in the maintenance of homeostasis in the body and at the onset of diseases such as inflammation, neurodegeneration, infection, diabetes, and cancer. It is also involved in bone metabolism. <i>N</i>- and <i>O</i>-glycans have been shown to regulate osteoblast and osteoclast differentiation. We recently demonstrated that ganglio-series and globo-series glycosphingolipids were essential for regulating the proliferation and differentiation of osteoblasts and osteoclasts in glycosyltransferase-knockout mice. Herein, we reviewed the importance of the regulation of bone metabolism by glycoconjugates, such as glycolipids and glycoproteins, including our recent results.https://www.mdpi.com/1422-0067/25/7/3568glycosylationglycosphingolipidsglycoproteinglycosyltransferaseosteoblastsosteoclasts |
| spellingShingle | Kazunori Hamamura Mayu Nagao Koichi Furukawa Regulation of Glycosylation in Bone Metabolism International Journal of Molecular Sciences glycosylation glycosphingolipids glycoprotein glycosyltransferase osteoblasts osteoclasts |
| title | Regulation of Glycosylation in Bone Metabolism |
| title_full | Regulation of Glycosylation in Bone Metabolism |
| title_fullStr | Regulation of Glycosylation in Bone Metabolism |
| title_full_unstemmed | Regulation of Glycosylation in Bone Metabolism |
| title_short | Regulation of Glycosylation in Bone Metabolism |
| title_sort | regulation of glycosylation in bone metabolism |
| topic | glycosylation glycosphingolipids glycoprotein glycosyltransferase osteoblasts osteoclasts |
| url | https://www.mdpi.com/1422-0067/25/7/3568 |
| work_keys_str_mv | AT kazunorihamamura regulationofglycosylationinbonemetabolism AT mayunagao regulationofglycosylationinbonemetabolism AT koichifurukawa regulationofglycosylationinbonemetabolism |