Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression
Skin cancers are the most common cancers worldwide. Among them, melanoma, basal cell carcinoma of the skin and cutaneous squamous cell carcinoma are the three major subtypes. These cancers are characterized by different genetic perturbations even though they are similarly caused by a lifelong exposu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/17/4362 |
| _version_ | 1797521589385822208 |
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| author | Alessandra Pecora Justine Laprise Manel Dahmene Mélanie Laurin |
| author_facet | Alessandra Pecora Justine Laprise Manel Dahmene Mélanie Laurin |
| author_sort | Alessandra Pecora |
| collection | DOAJ |
| description | Skin cancers are the most common cancers worldwide. Among them, melanoma, basal cell carcinoma of the skin and cutaneous squamous cell carcinoma are the three major subtypes. These cancers are characterized by different genetic perturbations even though they are similarly caused by a lifelong exposure to the sun. The main oncogenic drivers of skin cancer initiation have been known for a while, yet it remains unclear what are the molecular events that mediate their oncogenic functions and that contribute to their progression. Moreover, patients with aggressive skin cancers have been known to develop resistance to currently available treatment, which is urging us to identify new therapeutic opportunities based on a better understanding of skin cancer biology. More recently, the contribution of cytoskeletal dynamics and Rho GTPase signaling networks to the progression of skin cancers has been highlighted by several studies. In this review, we underline the various perturbations in the activity and regulation of Rho GTPase network components that contribute to skin cancer development, and we explore the emerging therapeutic opportunities that are surfacing from these studies. |
| first_indexed | 2024-03-10T08:14:38Z |
| format | Article |
| id | doaj.art-7a814da3d4b642f88935b1fc73195ec7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T08:14:38Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7a814da3d4b642f88935b1fc73195ec72023-11-22T10:26:15ZengMDPI AGCancers2072-66942021-08-011317436210.3390/cancers13174362Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their ProgressionAlessandra Pecora0Justine Laprise1Manel Dahmene2Mélanie Laurin3Oncology Division, CHU de Québec–Université Laval Research Center, Québec City, QC G1V 4G2, CanadaOncology Division, CHU de Québec–Université Laval Research Center, Québec City, QC G1V 4G2, CanadaOncology Division, CHU de Québec–Université Laval Research Center, Québec City, QC G1V 4G2, CanadaOncology Division, CHU de Québec–Université Laval Research Center, Québec City, QC G1V 4G2, CanadaSkin cancers are the most common cancers worldwide. Among them, melanoma, basal cell carcinoma of the skin and cutaneous squamous cell carcinoma are the three major subtypes. These cancers are characterized by different genetic perturbations even though they are similarly caused by a lifelong exposure to the sun. The main oncogenic drivers of skin cancer initiation have been known for a while, yet it remains unclear what are the molecular events that mediate their oncogenic functions and that contribute to their progression. Moreover, patients with aggressive skin cancers have been known to develop resistance to currently available treatment, which is urging us to identify new therapeutic opportunities based on a better understanding of skin cancer biology. More recently, the contribution of cytoskeletal dynamics and Rho GTPase signaling networks to the progression of skin cancers has been highlighted by several studies. In this review, we underline the various perturbations in the activity and regulation of Rho GTPase network components that contribute to skin cancer development, and we explore the emerging therapeutic opportunities that are surfacing from these studies.https://www.mdpi.com/2072-6694/13/17/4362Rho GTPaseRhoGEFRhoGAPskincancersquamous cell carcinoma |
| spellingShingle | Alessandra Pecora Justine Laprise Manel Dahmene Mélanie Laurin Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression Cancers Rho GTPase RhoGEF RhoGAP skin cancer squamous cell carcinoma |
| title | Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression |
| title_full | Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression |
| title_fullStr | Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression |
| title_full_unstemmed | Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression |
| title_short | Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression |
| title_sort | skin cancers and the contribution of rho gtpase signaling networks to their progression |
| topic | Rho GTPase RhoGEF RhoGAP skin cancer squamous cell carcinoma |
| url | https://www.mdpi.com/2072-6694/13/17/4362 |
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