Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep
Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defi ned as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-03-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2792 |
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| author | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN |
| author_facet | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN |
| author_sort | Jianlei JIA |
| collection | DOAJ |
| description | Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It
has been defi ned as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the
BMPR-1B gene 3"-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103
Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identifi ed, which were G1339A and
A1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354G
variant of the 3"UTR region, that AA and A were the preponderant genotype and allele, respectively. The χ2 independence test analyses indicated
that the A1354G variant of BMPR-1B gene 3"UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P<0.05).
These results demonstrate that the BMPR-1B gene 3"-UTR region might be a potential candidate gene for marker-assisted selection (MAS). |
| first_indexed | 2024-03-13T04:39:25Z |
| format | Article |
| id | doaj.art-7a81d1ee5d8d4184b79c9cb5767a54b8 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:25Z |
| publishDate | 2021-03-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-7a81d1ee5d8d4184b79c9cb5767a54b82023-06-19T06:29:55ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-03-0127328528910.9775/kvfd.2020.250642792Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheepJianlei JIA0Dejuan XIE1Yingying ZHANG2Huaixia ZHANG3Liping ZHANG4Shengzhen HOU5Qian CHEN6College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINACollege of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, PR CHINABone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. It has been defi ned as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in the BMPR-1B gene 3"-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103 Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identifi ed, which were G1339A and A1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354G variant of the 3"UTR region, that AA and A were the preponderant genotype and allele, respectively. The χ2 independence test analyses indicated that the A1354G variant of BMPR-1B gene 3"UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P<0.05). These results demonstrate that the BMPR-1B gene 3"-UTR region might be a potential candidate gene for marker-assisted selection (MAS).https://vetdergikafkas.org/pdf.php?id=2792tibetan sheepbmpr-1b gene3 |
| spellingShingle | Jianlei JIA Dejuan XIE Yingying ZHANG Huaixia ZHANG Liping ZHANG Shengzhen HOU Qian CHEN Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep Kafkas Universitesi Veteriner Fakültesi Dergisi tibetan sheep bmpr-1b gene 3 |
| title | Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep |
| title_full | Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep |
| title_fullStr | Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep |
| title_full_unstemmed | Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep |
| title_short | Association of bmpr-1b gene 3"-utr region polymorphism with litter size in tibetan sheep |
| title_sort | association of bmpr 1b gene 3 utr region polymorphism with litter size in tibetan sheep |
| topic | tibetan sheep bmpr-1b gene 3 |
| url | https://vetdergikafkas.org/pdf.php?id=2792 |
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