Threshold Effect Analysis of Influence of Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted Reproductive Technology
BackgroundPregnancy outcome in patients with poor ovarian response (POR) has always been one of the difficult problems in reproductive medicine, but there is few threshold effect analysis of influence of age on live birth rate in POR patients treated by assisted reproductive technology (ART) .Object...
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Chinese General Practice Publishing House Co., Ltd
2022-01-01
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1640773202545-284679092.pdf |
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| author | CHEN Ying, LI Fei, DILIXIATI•Abulizi, WU Xiao, REYILA•Mumin, FENG Xingmei, ZHANG Yali |
| author_facet | CHEN Ying, LI Fei, DILIXIATI•Abulizi, WU Xiao, REYILA•Mumin, FENG Xingmei, ZHANG Yali |
| author_sort | CHEN Ying, LI Fei, DILIXIATI•Abulizi, WU Xiao, REYILA•Mumin, FENG Xingmei, ZHANG Yali |
| collection | DOAJ |
| description | BackgroundPregnancy outcome in patients with poor ovarian response (POR) has always been one of the difficult problems in reproductive medicine, but there is few threshold effect analysis of influence of age on live birth rate in POR patients treated by assisted reproductive technology (ART) .ObjectiveTo analyze the threshold effect of influence of age on live birth rate in POR patients treated by ART.MethodsAmong 19 185 women who received routine in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and embryo transplantation in Department of Gynaecology and Obstetrics, the First People's Hospital of Shangqiu and Fertility Support Center, the First Affiliated Hospital of Xinjiang Medical University from August 2014 to December 2018, 3 337 patients with POR were selected, and received controlled ovarian stimulation, embryo transplantation by IVF/ICSI and luteal support therapy. The incidence of live birth was analyzed. Univariate and multivariate Logistic analyses were used to analyze the influence of age on live birth in POR patients treated by ART. Moreover, smooth curve fitting and threshold effect analysis were conducted.ResultsOf the 3 337 cases, 1 134 obtained a live birth, the other 2 203 did not, achieving a rate of live birth of 33.98% (1 134/3 337) . Multivariate Logistic analysis result showed that, age was independently associated with live birth in POR patients treated by ART〔OR=0.920, 95%CI (0.902, 0.939) , P<0.01〕. Smooth curve fitting showed that, age was negatively correlated with live birth rate in POR patients treated by ART, but the correlation was not simple linear. Threshold effect analysis results showed that, 32 years old was the threshold for decrease of live birth rate in POR patients treated by ART, namely age did not affect the live birth rate in those ≤32 years old〔OR=1.000, 95%CI (0.998, 1.012) , P=0.38〕, but the live birth rate decreased as age grew in those over 32 years old〔OR=0.800, 95%CI (0.799, 0.823) , P<0.01〕.ConclusionAge was an independent influencing factor of live birth in POR patients treated by ART. The live birth rate may decrease as age grows in these patients over 32 years old. |
| first_indexed | 2024-04-24T11:59:48Z |
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| id | doaj.art-7a821344269d4f4daf2f42045456a4ea |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:59:48Z |
| publishDate | 2022-01-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-7a821344269d4f4daf2f42045456a4ea2024-04-09T02:50:00ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-01-01250326426910.12114/j.issn.1007-9572.2021.02.093Threshold Effect Analysis of Influence of Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted Reproductive TechnologyCHEN Ying, LI Fei, DILIXIATI•Abulizi, WU Xiao, REYILA•Mumin, FENG Xingmei, ZHANG Yali0 1.Department of Gynaecology and Obstetrics，the First People's Hospital of Shangqiu，Shangqiu 476000，China 2.Fertility Support Center，the First Affiliated Hospital of Xinjiang Medical University，Urumqi 830000，China *Corresponding author：LI Fei，Attending physician；E-mail：xylaoli5@163.com BackgroundPregnancy outcome in patients with poor ovarian response (POR) has always been one of the difficult problems in reproductive medicine, but there is few threshold effect analysis of influence of age on live birth rate in POR patients treated by assisted reproductive technology (ART) .ObjectiveTo analyze the threshold effect of influence of age on live birth rate in POR patients treated by ART.MethodsAmong 19 185 women who received routine in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and embryo transplantation in Department of Gynaecology and Obstetrics, the First People's Hospital of Shangqiu and Fertility Support Center, the First Affiliated Hospital of Xinjiang Medical University from August 2014 to December 2018, 3 337 patients with POR were selected, and received controlled ovarian stimulation, embryo transplantation by IVF/ICSI and luteal support therapy. The incidence of live birth was analyzed. Univariate and multivariate Logistic analyses were used to analyze the influence of age on live birth in POR patients treated by ART. Moreover, smooth curve fitting and threshold effect analysis were conducted.ResultsOf the 3 337 cases, 1 134 obtained a live birth, the other 2 203 did not, achieving a rate of live birth of 33.98% (1 134/3 337) . Multivariate Logistic analysis result showed that, age was independently associated with live birth in POR patients treated by ART〔OR=0.920, 95%CI (0.902, 0.939) , P<0.01〕. Smooth curve fitting showed that, age was negatively correlated with live birth rate in POR patients treated by ART, but the correlation was not simple linear. Threshold effect analysis results showed that, 32 years old was the threshold for decrease of live birth rate in POR patients treated by ART, namely age did not affect the live birth rate in those ≤32 years old〔OR=1.000, 95%CI (0.998, 1.012) , P=0.38〕, but the live birth rate decreased as age grew in those over 32 years old〔OR=0.800, 95%CI (0.799, 0.823) , P<0.01〕.ConclusionAge was an independent influencing factor of live birth in POR patients treated by ART. The live birth rate may decrease as age grows in these patients over 32 years old.https://www.chinagp.net/fileup/1007-9572/PDF/1640773202545-284679092.pdf|reproductive techniques, assisted|ovary|poor ovarian response|pregnancy outcome|age factors|embryo transfer |
| spellingShingle | CHEN Ying, LI Fei, DILIXIATI•Abulizi, WU Xiao, REYILA•Mumin, FENG Xingmei, ZHANG Yali Threshold Effect Analysis of Influence of Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted Reproductive Technology Zhongguo quanke yixue |reproductive techniques, assisted|ovary|poor ovarian response|pregnancy outcome|age factors|embryo transfer |
| title | Threshold Effect Analysis of Influence of
Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted
Reproductive Technology |
| title_full | Threshold Effect Analysis of Influence of
Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted
Reproductive Technology |
| title_fullStr | Threshold Effect Analysis of Influence of
Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted
Reproductive Technology |
| title_full_unstemmed | Threshold Effect Analysis of Influence of
Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted
Reproductive Technology |
| title_short | Threshold Effect Analysis of Influence of
Age on Live Birth Rate in Poor Ovarian Response Patients Treated by Assisted
Reproductive Technology |
| title_sort | threshold effect analysis of influence of age on live birth rate in poor ovarian response patients treated by assisted reproductive technology |
| topic | |reproductive techniques, assisted|ovary|poor ovarian response|pregnancy outcome|age factors|embryo transfer |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1640773202545-284679092.pdf |
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