HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.

HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.

BACKGROUND: Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs). METHODS: The study includes 1568 NS3-protease sequences, isolated from PI-nai...

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Main Authors: Valeria Cento, Carmen Mirabelli, Romina Salpini, Salvatore Dimonte, Anna Artese, Giosuè Costa, Fabio Mercurio, Valentina Svicher, Lucia Parrotta, Ada Bertoli, Marco Ciotti, Daniele Di Paolo, Cesare Sarrecchia, Massimo Andreoni, Stefano Alcaro, Mario Angelico, Carlo Federico Perno, Francesca Ceccherini-Silberstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3391197?pdf=render

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