Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats
Introduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino acids from skeletal muscles are observed. Changes in the amino acid system of skeletal muscles may be responsible for the occurrence of muscl...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2016-12-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jvetres-2016-0072 |
| _version_ | 1818715300629053440 |
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| author | Gołyński Marcin Szpetnar Maria Tatara Marcin R. Lutnicki Krzysztof Gołyńska Magdalena Kurek Łukasz Szczepanik Marcin Wilkołek Piotr |
| author_facet | Gołyński Marcin Szpetnar Maria Tatara Marcin R. Lutnicki Krzysztof Gołyńska Magdalena Kurek Łukasz Szczepanik Marcin Wilkołek Piotr |
| author_sort | Gołyński Marcin |
| collection | DOAJ |
| description | Introduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino acids from skeletal muscles are observed. Changes in the amino acid system of skeletal muscles may be responsible for the occurrence of muscle disorders. Material and Methods: The study measured the content of selected amino acids in the gastrocnemius muscle of Wistar rats during experimental hypothyroidism induced by oral administration of methimazole at a concentration of 0.05% in drinking water for 90 d. The rats were divided into four groups: E1 (n = 6) - experimental males, E2 (n = 6) - experimental females, C1 (n = 6) - control males, and C2 (n = 6) control females. Results: A statistically significant reduction occurred in leucine, isoleucine, and 1-methylhistidine levels in males, and 1-methylhistidine in females, in comparison to the control groups. Conclusion: The hypothyroidism-induced changes in amino acid content may be responsible for the occurrence of skeletal muscle function disorders. |
| first_indexed | 2024-12-17T19:01:11Z |
| format | Article |
| id | doaj.art-7a837ebd451d4df180b8660df364b5a1 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-12-17T19:01:11Z |
| publishDate | 2016-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-7a837ebd451d4df180b8660df364b5a12022-12-21T21:36:06ZengSciendoJournal of Veterinary Research2450-86082016-12-0160448949310.1515/jvetres-2016-0072jvetres-2016-0072Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in ratsGołyński Marcin0Szpetnar Maria1Tatara Marcin R.2Lutnicki Krzysztof3Gołyńska Magdalena4Kurek Łukasz5Szczepanik Marcin6Wilkołek Piotr7Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandChair and Department of Medical Chemistry, Medical University, 20-093 Lublin, PolandDepartment of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandDepartment and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, PolandIntroduction: Thyroid hormones affect protein turnover, and in the case of hypothyroidism a decrease in protein synthesis and reduced release of certain amino acids from skeletal muscles are observed. Changes in the amino acid system of skeletal muscles may be responsible for the occurrence of muscle disorders. Material and Methods: The study measured the content of selected amino acids in the gastrocnemius muscle of Wistar rats during experimental hypothyroidism induced by oral administration of methimazole at a concentration of 0.05% in drinking water for 90 d. The rats were divided into four groups: E1 (n = 6) - experimental males, E2 (n = 6) - experimental females, C1 (n = 6) - control males, and C2 (n = 6) control females. Results: A statistically significant reduction occurred in leucine, isoleucine, and 1-methylhistidine levels in males, and 1-methylhistidine in females, in comparison to the control groups. Conclusion: The hypothyroidism-induced changes in amino acid content may be responsible for the occurrence of skeletal muscle function disorders.https://doi.org/10.1515/jvetres-2016-0072ratshypothyroidismamino acidsmuscle |
| spellingShingle | Gołyński Marcin Szpetnar Maria Tatara Marcin R. Lutnicki Krzysztof Gołyńska Magdalena Kurek Łukasz Szczepanik Marcin Wilkołek Piotr Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats Journal of Veterinary Research rats hypothyroidism amino acids muscle |
| title | Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| title_full | Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| title_fullStr | Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| title_full_unstemmed | Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| title_short | Content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| title_sort | content of selected amino acids in the gastrocnemius muscle during experimental hypothyroidism in rats |
| topic | rats hypothyroidism amino acids muscle |
| url | https://doi.org/10.1515/jvetres-2016-0072 |
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