The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients
Abstract Although hypertension is considered high intravascular pressure, impairing circadian blood pressure (BP) has been shown to potentially contribute to poor clinical outcomes. Systemic immune‐inflammation index (SII), based on platelet, neutrophil, and lymphocyte counts, has been established a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14688 |
| _version_ | 1797645237114372096 |
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| author | Muammer Karakayali Timor Omar Inanç Artac İbrahim Rencuzogullari Yavuz Karabag Ozturk Demir |
| author_facet | Muammer Karakayali Timor Omar Inanç Artac İbrahim Rencuzogullari Yavuz Karabag Ozturk Demir |
| author_sort | Muammer Karakayali |
| collection | DOAJ |
| description | Abstract Although hypertension is considered high intravascular pressure, impairing circadian blood pressure (BP) has been shown to potentially contribute to poor clinical outcomes. Systemic immune‐inflammation index (SII), based on platelet, neutrophil, and lymphocyte counts, has been established as a strong prognostic marker in cardiovascular disease. The role of inflammation in the pathogenesis of hypertension is a well‐known issue and inflammatory markers are associated with BP variability. We aimed to investigate whether there is a relationship between circadian BP changes and SII in newly diagnosed hypertensive patients. The study population consisted of 196 newly diagnosed hypertensive patients without LVH. In total, 76 (38%) patients had a dipper BP pattern, 60 (31%) patients had a non‐dipper BP pattern, and 60 (31%) patients had a reverse‐dipper BP pattern. SII was calculated according to Multivariate logistic regression analysis revealed SII and HDL‐C as an independent predictors of reverse‐dipper circadian pattern in newly diagnosed hypertensive patients. The cut‐off value of the SII for reverse‐dipper hypertension in a ROC curve analysis was >639.73 with 63.3% sensitivity and 84.2% specificity. Our study showed that the SII level was higher in the reverse‐dipper hypertension patient group than in the dipper and non‐dipper hypertension groups. Furthermore, SII was an independent predictor of newly diagnosed reverse‐dipper hypertensive patients. The high SII value in newly diagnosed hypertensive patients can be used as an early warning parameter to identify reverse‐dipper hypertension patients. |
| first_indexed | 2024-03-11T14:43:25Z |
| format | Article |
| id | doaj.art-7a838f9093e64f1e962644001cf838bb |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:25Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-7a838f9093e64f1e962644001cf838bb2023-10-30T13:25:57ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762023-08-0125870070710.1111/jch.14688The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patientsMuammer Karakayali0Timor Omar1Inanç Artac2İbrahim Rencuzogullari3Yavuz Karabag4Ozturk Demir5Department of Cardiology Kafkas University School of Medicine KarsTurkeyDepartment of Cardiology Kafkas University School of Medicine KarsTurkeyDepartment of Cardiology Kafkas University School of Medicine KarsTurkeyDepartment of Cardiology Kafkas University School of Medicine KarsTurkeyDepartment of Cardiology Kafkas University School of Medicine KarsTurkeyDepartment of Cardiology Kafkas University School of Medicine KarsTurkeyAbstract Although hypertension is considered high intravascular pressure, impairing circadian blood pressure (BP) has been shown to potentially contribute to poor clinical outcomes. Systemic immune‐inflammation index (SII), based on platelet, neutrophil, and lymphocyte counts, has been established as a strong prognostic marker in cardiovascular disease. The role of inflammation in the pathogenesis of hypertension is a well‐known issue and inflammatory markers are associated with BP variability. We aimed to investigate whether there is a relationship between circadian BP changes and SII in newly diagnosed hypertensive patients. The study population consisted of 196 newly diagnosed hypertensive patients without LVH. In total, 76 (38%) patients had a dipper BP pattern, 60 (31%) patients had a non‐dipper BP pattern, and 60 (31%) patients had a reverse‐dipper BP pattern. SII was calculated according to Multivariate logistic regression analysis revealed SII and HDL‐C as an independent predictors of reverse‐dipper circadian pattern in newly diagnosed hypertensive patients. The cut‐off value of the SII for reverse‐dipper hypertension in a ROC curve analysis was >639.73 with 63.3% sensitivity and 84.2% specificity. Our study showed that the SII level was higher in the reverse‐dipper hypertension patient group than in the dipper and non‐dipper hypertension groups. Furthermore, SII was an independent predictor of newly diagnosed reverse‐dipper hypertensive patients. The high SII value in newly diagnosed hypertensive patients can be used as an early warning parameter to identify reverse‐dipper hypertension patients.https://doi.org/10.1111/jch.14688ambulatory blood pressure monitoringcircadian blood pressure, hypertension, reverse‐dipper, Systemic immune‐inflammation index |
| spellingShingle | Muammer Karakayali Timor Omar Inanç Artac İbrahim Rencuzogullari Yavuz Karabag Ozturk Demir The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients The Journal of Clinical Hypertension ambulatory blood pressure monitoring circadian blood pressure, hypertension, reverse‐dipper, Systemic immune‐inflammation index |
| title | The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients |
| title_full | The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients |
| title_fullStr | The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients |
| title_full_unstemmed | The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients |
| title_short | The relationship between the systemic immune‐inflammation index and reverse‐dipper circadian pattern in newly diagnosed hypertensive patients |
| title_sort | relationship between the systemic immune inflammation index and reverse dipper circadian pattern in newly diagnosed hypertensive patients |
| topic | ambulatory blood pressure monitoring circadian blood pressure, hypertension, reverse‐dipper, Systemic immune‐inflammation index |
| url | https://doi.org/10.1111/jch.14688 |
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