Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients
Objective: In this study, the effect of in vitro Fertilization-Embryo Transfer (IVF-ET) on the clinical outcome of patients with syphilis infertility during resuscitation cycle. Methods: A retrospective single-center method was adopted. This study included 4430 pairs of infertile patients who underw...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024053738 |
| _version_ | 1827261845589721088 |
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| author | Lixia Miao Lishuang Xu Min Wang Fang Xiong Lian Zou Yun Zhang Meiling Weng Huiming Zeng |
| author_facet | Lixia Miao Lishuang Xu Min Wang Fang Xiong Lian Zou Yun Zhang Meiling Weng Huiming Zeng |
| author_sort | Lixia Miao |
| collection | DOAJ |
| description | Objective: In this study, the effect of in vitro Fertilization-Embryo Transfer (IVF-ET) on the clinical outcome of patients with syphilis infertility during resuscitation cycle. Methods: A retrospective single-center method was adopted. This study included 4430 pairs of infertile patients who underwent syphilis detection. The influence of the syphilis freeze-thaw embryos transplantation outcome was studied in the patients with infertility by comparing the general clinical characteristics of patients (age, years of infertility, body mass index (BMI), basal follicle stimulating hormone (FSH), serum basal estradiol (Estradiol, E2), transplanted intimal thickness, the number of embryos transferred) and the clinical pregnancy (biochemical pregnancy rate, clinical pregnancy rate, implantation rate, live birth rate and abortion rate). Results: Firstly, in the clinical outcome of one frozen-thawed embryos transfer, the live birth rate of the woman's syphilis-infected group was lower than that of the uninfected group (71.3 % vs. 50.0 %), while the abortion rate was higher than that of the uninfected group (7.8 % vs. 26.7 %), and there was a statistical difference (P < 0.05), and there was no statistical difference in other indicators between other groups (P > 0.05). Secondly, in the clinical outcome of two frozen-thawed embryos transfers, the biochemical pregnancy rate (61.3 % vs. 28.6 %) and clinical pregnancy rate (42.9 % vs. 14.3 %) of the group which was infected with syphilis alone were lower than those of the uninfected group (P < 0.05), and other indicators among the other groups showed no statistical difference (P > 0.05). Thirdly, in the clinical outcomes of frozen-thawed embryos transfer three times or more, there was no significant difference in the clinical indicators between the syphilis infertility patients and the non-infected infertility patients (P > 0.05). Conclusion: When the syphilis infertility patients and the non-infected infertile patients underwent IVF-ET treatment for the first time, the live birth rate and abortion rate of the syphilis group were significantly different (P < 0.05). In the outcome of two transplants, the biochemical pregnancy rate and clinical Pregnancy rates were significantly reduced so patients with syphilis infertility who undergo IVF-ET should be informed about the risk of adverse clinical outcomes. |
| first_indexed | 2024-04-24T10:57:28Z |
| format | Article |
| id | doaj.art-7a86552f2fce412ca9d44ef605b9ebb5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2025-03-22T03:04:51Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj.art-7a86552f2fce412ca9d44ef605b9ebb52024-05-01T05:08:36ZengElsevierHeliyon2405-84402024-04-01108e29342Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patientsLixia Miao0Lishuang Xu1Min Wang2Fang Xiong3Lian Zou4Yun Zhang5Meiling Weng6Huiming Zeng7Wuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaWuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaCorresponding author.; Wuxi Maternity and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Wuxi, 214002, Jiangsu, ChinaObjective: In this study, the effect of in vitro Fertilization-Embryo Transfer (IVF-ET) on the clinical outcome of patients with syphilis infertility during resuscitation cycle. Methods: A retrospective single-center method was adopted. This study included 4430 pairs of infertile patients who underwent syphilis detection. The influence of the syphilis freeze-thaw embryos transplantation outcome was studied in the patients with infertility by comparing the general clinical characteristics of patients (age, years of infertility, body mass index (BMI), basal follicle stimulating hormone (FSH), serum basal estradiol (Estradiol, E2), transplanted intimal thickness, the number of embryos transferred) and the clinical pregnancy (biochemical pregnancy rate, clinical pregnancy rate, implantation rate, live birth rate and abortion rate). Results: Firstly, in the clinical outcome of one frozen-thawed embryos transfer, the live birth rate of the woman's syphilis-infected group was lower than that of the uninfected group (71.3 % vs. 50.0 %), while the abortion rate was higher than that of the uninfected group (7.8 % vs. 26.7 %), and there was a statistical difference (P < 0.05), and there was no statistical difference in other indicators between other groups (P > 0.05). Secondly, in the clinical outcome of two frozen-thawed embryos transfers, the biochemical pregnancy rate (61.3 % vs. 28.6 %) and clinical pregnancy rate (42.9 % vs. 14.3 %) of the group which was infected with syphilis alone were lower than those of the uninfected group (P < 0.05), and other indicators among the other groups showed no statistical difference (P > 0.05). Thirdly, in the clinical outcomes of frozen-thawed embryos transfer three times or more, there was no significant difference in the clinical indicators between the syphilis infertility patients and the non-infected infertility patients (P > 0.05). Conclusion: When the syphilis infertility patients and the non-infected infertile patients underwent IVF-ET treatment for the first time, the live birth rate and abortion rate of the syphilis group were significantly different (P < 0.05). In the outcome of two transplants, the biochemical pregnancy rate and clinical Pregnancy rates were significantly reduced so patients with syphilis infertility who undergo IVF-ET should be informed about the risk of adverse clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2405844024053738Syphilis infectionFrozen-thawed embryosIVF-ETClinical results |
| spellingShingle | Lixia Miao Lishuang Xu Min Wang Fang Xiong Lian Zou Yun Zhang Meiling Weng Huiming Zeng Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients Heliyon Syphilis infection Frozen-thawed embryos IVF-ET Clinical results |
| title | Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients |
| title_full | Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients |
| title_fullStr | Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients |
| title_full_unstemmed | Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients |
| title_short | Study on the influence of syphilis on the outcome of frozen-thawed embryo transfer in infertility patients |
| title_sort | study on the influence of syphilis on the outcome of frozen thawed embryo transfer in infertility patients |
| topic | Syphilis infection Frozen-thawed embryos IVF-ET Clinical results |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024053738 |
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