Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats
The aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms. An intraperitoneal injection of 3 mg/kg METH was used for CPP training in rats. The effects of Jinniu Capsule foll...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2018-08-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2018-0074 |
| _version_ | 1818720312638832640 |
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| author | Shi Yu Wang Feng Hu A-Zhen Wang Qing-Wen Wu Jue-Lian Li Ming-Hua Cui Guang-Hui Liu Li Huang Si-Bin Zhang Yu Liu Han-Qing Chen Yun |
| author_facet | Shi Yu Wang Feng Hu A-Zhen Wang Qing-Wen Wu Jue-Lian Li Ming-Hua Cui Guang-Hui Liu Li Huang Si-Bin Zhang Yu Liu Han-Qing Chen Yun |
| author_sort | Shi Yu |
| collection | DOAJ |
| description | The aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms. An intraperitoneal injection of 3 mg/kg METH was used for CPP training in rats. The effects of Jinniu Capsule following a single dose on rat CPP and repeat dosing on METH withdrawal were evaluated. Western Blot analysis was used to measure protein expression of the PI3K-AKT-mTOR signaling pathway to determine the mechanisms of Jinniu Capsule. A single dose of Jinniu Capsule did not influence METH-induced CPP in rats. However, repeat dosing for 7 days significantly promoted METH withdrawal. Furthermore, METH withdrawal activated the PI3K-AKT-mTOR signaling pathway phosphorylation cascade, and Jinniu Capsule partly blocked this cascade. Jinniu Capsule demonstrated potential in promoting METH withdrawal in a rat CPP model, which may be related to its influence on the PI3K-AKT-mTOR signaling pathway. |
| first_indexed | 2024-12-17T20:20:50Z |
| format | Article |
| id | doaj.art-7a869c3c9887486d9e8c86c947827db0 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-12-17T20:20:50Z |
| publishDate | 2018-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-7a869c3c9887486d9e8c86c947827db02022-12-21T21:33:57ZengDe GruyterOpen Chemistry2391-54202018-08-0116167468010.1515/chem-2018-0074chem-2018-0074Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in RatsShi Yu0Wang Feng1Hu A-Zhen2Wang Qing-Wen3Wu Jue-Lian4Li Ming-Hua5Cui Guang-Hui6Liu Li7Huang Si-Bin8Zhang Yu9Liu Han-Qing10Chen Yun11Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Department of Physiology and Neurobiology, Xinxiang Medical University, No. 601 of Jinsui avenue, Hongqi district, Xinxiang, Henan, China, 453000Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Xia men 929 bioproducts Co., Ltd, Xia men, Fujian, China, 361100Department of Ultrasound, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, China, 5180515Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036Peking University Shenzhen Hospital, Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120 of Lianhua Road, Futian district, Shenzhen, Guangdong, China, 518036The aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms. An intraperitoneal injection of 3 mg/kg METH was used for CPP training in rats. The effects of Jinniu Capsule following a single dose on rat CPP and repeat dosing on METH withdrawal were evaluated. Western Blot analysis was used to measure protein expression of the PI3K-AKT-mTOR signaling pathway to determine the mechanisms of Jinniu Capsule. A single dose of Jinniu Capsule did not influence METH-induced CPP in rats. However, repeat dosing for 7 days significantly promoted METH withdrawal. Furthermore, METH withdrawal activated the PI3K-AKT-mTOR signaling pathway phosphorylation cascade, and Jinniu Capsule partly blocked this cascade. Jinniu Capsule demonstrated potential in promoting METH withdrawal in a rat CPP model, which may be related to its influence on the PI3K-AKT-mTOR signaling pathway.https://doi.org/10.1515/chem-2018-0074methamphetamineconditioned place preferencejinniu capsulewithdrawalmtor signaling pathway |
| spellingShingle | Shi Yu Wang Feng Hu A-Zhen Wang Qing-Wen Wu Jue-Lian Li Ming-Hua Cui Guang-Hui Liu Li Huang Si-Bin Zhang Yu Liu Han-Qing Chen Yun Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats Open Chemistry methamphetamine conditioned place preference jinniu capsule withdrawal mtor signaling pathway |
| title | Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats |
| title_full | Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats |
| title_fullStr | Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats |
| title_full_unstemmed | Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats |
| title_short | Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats |
| title_sort | effects and mechanisms of jinniu capsule on methamphetamine induced conditioned place preference in rats |
| topic | methamphetamine conditioned place preference jinniu capsule withdrawal mtor signaling pathway |
| url | https://doi.org/10.1515/chem-2018-0074 |
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