Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice

Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice

Background: Remifentanil, a synthetic opioid used for analgesia during cesarean sections, has been shown in ex vivo experiments to exert anti-apoptotic activity on immature mice brains. The present study aimed to characterize the impact of remifentanil on brain lesions using an in vivo model of exci...

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Bibliographic Details
Main Authors: Clément Chollat, Maryline Lecointre, Matthieu Leuillier, Isabelle Remy-Jouet, Jean-Claude Do Rego, Lénaïg Abily-Donval, Yasmina Ramdani, Vincent Richard, Patricia Compagnon, Bertrand Dureuil, Stéphane Marret, Bruno José Gonzalez, Sylvie Jégou, Fabien Tourrel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neurology
Subjects:
anesthetics
preterm birth
ibotenate
neurotoxicity
cell death
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00407/full

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