Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes
Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as “domestication syndrome.” These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically reduced adrenocorticotropic hormone release f...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2018-03-01
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| Series: | G3: Genes, Genomes, Genetics |
| Subjects: | |
| Online Access: | http://g3journal.org/lookup/doi/10.1534/g3.117.300508 |
| _version_ | 1818891477367914496 |
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| author | Jessica P. Hekman Jennifer L. Johnson Whitney Edwards Anastasiya V. Vladimirova Rimma G. Gulevich Alexandra L. Ford Anastasiya V. Kharlamova Yury Herbeck Gregory M. Acland Lori T. Raetzman Lyudmila N. Trut Anna V. Kukekova |
| author_facet | Jessica P. Hekman Jennifer L. Johnson Whitney Edwards Anastasiya V. Vladimirova Rimma G. Gulevich Alexandra L. Ford Anastasiya V. Kharlamova Yury Herbeck Gregory M. Acland Lori T. Raetzman Lyudmila N. Trut Anna V. Kukekova |
| author_sort | Jessica P. Hekman |
| collection | DOAJ |
| description | Domesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as “domestication syndrome.” These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically reduced adrenocorticotropic hormone release from the anterior pituitary. To investigate the biological mechanisms targeted during domestication, we investigated gene expression in the pituitaries of experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced from the anterior pituitary of six foxes selectively bred for tameness (“tame foxes”) and six foxes selectively bred for aggression (“aggressive foxes”). Expression, splicing, and network differences identified between the two lines indicated the importance of genes related to regulation of exocytosis, specifically mediated by cAMP, organization of pseudopodia, and cell motility. These findings provide new insights into biological mechanisms that may have been targeted when these lines of foxes were selected for behavior and suggest new directions for research into HPA axis regulation and the biological underpinnings of domestication. |
| first_indexed | 2024-12-19T17:41:26Z |
| format | Article |
| id | doaj.art-7a888c7b8ec24bbb9ae1587b2078fc42 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-12-19T17:41:26Z |
| publishDate | 2018-03-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-7a888c7b8ec24bbb9ae1587b2078fc422022-12-21T20:12:12ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362018-03-018385987310.1534/g3.117.30050812Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive FoxesJessica P. HekmanJennifer L. JohnsonWhitney EdwardsAnastasiya V. VladimirovaRimma G. GulevichAlexandra L. FordAnastasiya V. KharlamovaYury HerbeckGregory M. AclandLori T. RaetzmanLyudmila N. TrutAnna V. KukekovaDomesticated species exhibit a suite of behavioral, endocrinological, and morphological changes referred to as “domestication syndrome.” These changes may include a reduction in reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and specifically reduced adrenocorticotropic hormone release from the anterior pituitary. To investigate the biological mechanisms targeted during domestication, we investigated gene expression in the pituitaries of experimentally domesticated foxes (Vulpes vulpes). RNA was sequenced from the anterior pituitary of six foxes selectively bred for tameness (“tame foxes”) and six foxes selectively bred for aggression (“aggressive foxes”). Expression, splicing, and network differences identified between the two lines indicated the importance of genes related to regulation of exocytosis, specifically mediated by cAMP, organization of pseudopodia, and cell motility. These findings provide new insights into biological mechanisms that may have been targeted when these lines of foxes were selected for behavior and suggest new directions for research into HPA axis regulation and the biological underpinnings of domestication.http://g3journal.org/lookup/doi/10.1534/g3.117.300508RNA-seqpituitarydomesticationhypothalamic-pituitary-adrenal axisVulpes vulpes |
| spellingShingle | Jessica P. Hekman Jennifer L. Johnson Whitney Edwards Anastasiya V. Vladimirova Rimma G. Gulevich Alexandra L. Ford Anastasiya V. Kharlamova Yury Herbeck Gregory M. Acland Lori T. Raetzman Lyudmila N. Trut Anna V. Kukekova Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes G3: Genes, Genomes, Genetics RNA-seq pituitary domestication hypothalamic-pituitary-adrenal axis Vulpes vulpes |
| title | Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes |
| title_full | Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes |
| title_fullStr | Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes |
| title_full_unstemmed | Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes |
| title_short | Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes |
| title_sort | anterior pituitary transcriptome suggests differences in acth release in tame and aggressive foxes |
| topic | RNA-seq pituitary domestication hypothalamic-pituitary-adrenal axis Vulpes vulpes |
| url | http://g3journal.org/lookup/doi/10.1534/g3.117.300508 |
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