Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones
Chalcones are a type of natural flavonoid compound that have been found to possess promising anticancer properties. Studies have shown that chalcones can inhibit the growth and proliferation of cancer cells, induce apoptosis, and suppress tumor angiogenesis. In addition to their potential therapeuti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/6/1092 |
| _version_ | 1797241733096931328 |
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| author | Violetta Krajka-Kuźniak Marta Belka Katarzyna Papierska |
| author_facet | Violetta Krajka-Kuźniak Marta Belka Katarzyna Papierska |
| author_sort | Violetta Krajka-Kuźniak |
| collection | DOAJ |
| description | Chalcones are a type of natural flavonoid compound that have been found to possess promising anticancer properties. Studies have shown that chalcones can inhibit the growth and proliferation of cancer cells, induce apoptosis, and suppress tumor angiogenesis. In addition to their potential therapeutic applications, chalcones have also been studied for their chemopreventive effects, which involve reducing the risk of cancer development in healthy individuals. Overall, the anticancer properties of chalcones make them a promising area of research for developing new cancer treatments and preventative strategies. This review aims to provide a thorough overview of the central studies reported in the literature concerning cancer prevention and the treatment of chalcones. Although chalcones target many different mechanisms, the STAT and NF-κB signaling pathways are the ones this review will focus on, highlighting the existing crosstalk between these two pathways and considering the potential therapeutic opportunities for chalcone combinations. |
| first_indexed | 2024-04-24T18:28:01Z |
| format | Article |
| id | doaj.art-7a88cbee4d264cc9bf9ec17e7786e0d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T18:28:01Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7a88cbee4d264cc9bf9ec17e7786e0d32024-03-27T13:29:49ZengMDPI AGCancers2072-66942024-03-01166109210.3390/cancers16061092Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of ChalconesVioletta Krajka-Kuźniak0Marta Belka1Katarzyna Papierska2Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandChalcones are a type of natural flavonoid compound that have been found to possess promising anticancer properties. Studies have shown that chalcones can inhibit the growth and proliferation of cancer cells, induce apoptosis, and suppress tumor angiogenesis. In addition to their potential therapeutic applications, chalcones have also been studied for their chemopreventive effects, which involve reducing the risk of cancer development in healthy individuals. Overall, the anticancer properties of chalcones make them a promising area of research for developing new cancer treatments and preventative strategies. This review aims to provide a thorough overview of the central studies reported in the literature concerning cancer prevention and the treatment of chalcones. Although chalcones target many different mechanisms, the STAT and NF-κB signaling pathways are the ones this review will focus on, highlighting the existing crosstalk between these two pathways and considering the potential therapeutic opportunities for chalcone combinations.https://www.mdpi.com/2072-6694/16/6/1092chalconesSTAT signaling pathwayNF-κB signaling pathwaycancer preventionchalcones nanoformulationscancer treatment |
| spellingShingle | Violetta Krajka-Kuźniak Marta Belka Katarzyna Papierska Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones Cancers chalcones STAT signaling pathway NF-κB signaling pathway cancer prevention chalcones nanoformulations cancer treatment |
| title | Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones |
| title_full | Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones |
| title_fullStr | Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones |
| title_full_unstemmed | Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones |
| title_short | Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones |
| title_sort | targeting stat3 and nf κb signaling pathways in cancer prevention and treatment the role of chalcones |
| topic | chalcones STAT signaling pathway NF-κB signaling pathway cancer prevention chalcones nanoformulations cancer treatment |
| url | https://www.mdpi.com/2072-6694/16/6/1092 |
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