Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Abstract Background Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation. Indoleamine 2,3-dioxygenase is expressed in many cancer types, including breast cancer. Here, we analyze kynurenine and...

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Bibliographic Details
Main Authors: Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours, Guy Jerusalem
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
Indoleamine 2,3-dioxygenase
Kynurenine
Tryptophan
Kynurenine/tryptophan ratio
Immune system
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s12967-019-1984-2

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