Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
Background and aimPatients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfectionMethodsWe searched Pubmed/MEDLINE, EMBASE, Scopu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.992743/full |
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| author | Kevin Flores-Lovon Kevin Flores-Lovon Brando Ortiz-Saavedra Brando Ortiz-Saavedra Luis A. Cueva-Chicaña Luis A. Cueva-Chicaña Shalom Aperrigue-Lira Shalom Aperrigue-Lira Elizbet S. Montes-Madariaga Elizbet S. Montes-Madariaga David R. Soriano-Moreno Brett Bell Rodney Macedo Rodney Macedo |
| author_facet | Kevin Flores-Lovon Kevin Flores-Lovon Brando Ortiz-Saavedra Brando Ortiz-Saavedra Luis A. Cueva-Chicaña Luis A. Cueva-Chicaña Shalom Aperrigue-Lira Shalom Aperrigue-Lira Elizbet S. Montes-Madariaga Elizbet S. Montes-Madariaga David R. Soriano-Moreno Brett Bell Rodney Macedo Rodney Macedo |
| author_sort | Kevin Flores-Lovon |
| collection | DOAJ |
| description | Background and aimPatients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfectionMethodsWe searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone.ResultsFour cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19.ConclusionAlthough the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge. |
| first_indexed | 2024-12-10T18:23:45Z |
| format | Article |
| id | doaj.art-7a8aac84f5ae481e81ac825bb95b0472 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T18:23:45Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7a8aac84f5ae481e81ac825bb95b04722022-12-22T01:38:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.992743992743Immune responses in COVID-19 and tuberculosis coinfection: A scoping reviewKevin Flores-Lovon0Kevin Flores-Lovon1Brando Ortiz-Saavedra2Brando Ortiz-Saavedra3Luis A. Cueva-Chicaña4Luis A. Cueva-Chicaña5Shalom Aperrigue-Lira6Shalom Aperrigue-Lira7Elizbet S. Montes-Madariaga8Elizbet S. Montes-Madariaga9David R. Soriano-Moreno10Brett Bell11Rodney Macedo12Rodney Macedo13Universidad Nacional de San Agustín de Arequipa, Arequipa, PeruGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruUniversidad Nacional de San Agustín de Arequipa, Arequipa, PeruGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruUniversidad Nacional de San Agustín de Arequipa, Arequipa, PeruGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruUniversidad Nacional de San Agustín de Arequipa, Arequipa, PeruGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruUniversidad Nacional de San Agustín de Arequipa, Arequipa, PeruGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruUnidad de Investigación Clínica y Epidemiológica, Universidad Peruana Unión, Lima, PeruDepartment of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, United StatesGrupo de Investigación en Inmunología – GII, UNSA, Arequipa, PeruDepartment of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, United StatesBackground and aimPatients with COVID-19 and tuberculosis coinfection are at an increased risk of severe disease and death. We therefore sought to evaluate the current evidence which assessed the immune response in COVID-19 and tuberculosis coinfectionMethodsWe searched Pubmed/MEDLINE, EMBASE, Scopus, and Web of Science to identify articles published between 2020 and 2021. We included observational studies evaluating the immune response in patients with tuberculosis and COVID-19 compared to patients with COVID-19 alone.ResultsFour cross-sectional studies (372 participants) were identified. In patients with asymptomatic COVID-19 and latent tuberculosis (LTBI), increased cytokines, chemokines, growth factors and humoral responses were found. In addition, patients with symptomatic COVID-19 and LTBI had higher leukocytes counts and less inflammation. Regarding patients with COVID-19 and active tuberculosis (aTB), they exhibited decreased total lymphocyte counts, CD4 T cells specific against SARS-CoV-2 and responsiveness to SARS-CoV-2 antigens compared to patients with only COVID-19.ConclusionAlthough the evidence is limited, an apparent positive immunomodulation is observed in patients with COVID-19 and LTBI. On the other hand, patients with COVID-19 and aTB present a dysregulated immune response. Longitudinal studies are needed to confirm these findings and expand knowledge.https://www.frontiersin.org/articles/10.3389/fimmu.2022.992743/fullCOVID-19SARS-CoV-2tuberculosisMycobacterium tuberculosiscoinfectionimmunity |
| spellingShingle | Kevin Flores-Lovon Kevin Flores-Lovon Brando Ortiz-Saavedra Brando Ortiz-Saavedra Luis A. Cueva-Chicaña Luis A. Cueva-Chicaña Shalom Aperrigue-Lira Shalom Aperrigue-Lira Elizbet S. Montes-Madariaga Elizbet S. Montes-Madariaga David R. Soriano-Moreno Brett Bell Rodney Macedo Rodney Macedo Immune responses in COVID-19 and tuberculosis coinfection: A scoping review Frontiers in Immunology COVID-19 SARS-CoV-2 tuberculosis Mycobacterium tuberculosis coinfection immunity |
| title | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_full | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_fullStr | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_full_unstemmed | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_short | Immune responses in COVID-19 and tuberculosis coinfection: A scoping review |
| title_sort | immune responses in covid 19 and tuberculosis coinfection a scoping review |
| topic | COVID-19 SARS-CoV-2 tuberculosis Mycobacterium tuberculosis coinfection immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.992743/full |
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