Expression of functional eGFP-fused antigen-binding fragment of ranibizumab in Pichia pastoris

Expression of functional eGFP-fused antigen-binding fragment of ranibizumab in Pichia pastoris

Introduction: Ranibizumab is a mouse monoclonal antibody fragment antigen-binding (Fab) against human vascular endothelial growth factor-A (VEGF-A), inhibiting angiogenesis. This antibody is commercially produced in Escherichia coli host and used to treat wet age-related macular degeneration (AMD).M...

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Bibliographic Details
Main Authors: Shirin Movaghar Asareh, Tahereh Savei, Sareh Arjmand, Seyed Omid Ranaei Siadat, Fataneh Fatemi, Mehrab Pourmadadi, Javad Shabani Shayeh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-05-01
Series:BioImpacts
Subjects:
ranibizumab
fab fragment
vegf-a
pichia pastoris
split reporter
egfp
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-12-203.pdf

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