Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats
Background: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. Objectives: The presen...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Journal of Ayurveda and Integrative Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947622001115 |
| _version_ | 1797978842713817088 |
|---|---|
| author | S.M. Gunjegaonkar V.R. Khakal A.A. Joshi S.L. Nargund S.D. Shinde N.S. Khan |
| author_facet | S.M. Gunjegaonkar V.R. Khakal A.A. Joshi S.L. Nargund S.D. Shinde N.S. Khan |
| author_sort | S.M. Gunjegaonkar |
| collection | DOAJ |
| description | Background: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. Objectives: The present study aimed to find the cardio-protective effect of CH in experimental hypertension in rats. Materials and methods: For acute renal hypertension, CH animals were pre-treated with CH-1 (250 mg/kg) and CH-2 (500 mg/kg) p. o. for 14 days. On the 15th day, hypertension was induced by renal occlusion and the mean arterial blood pressure (MABP) was recorded. For CAL pretreatment of CH-1 and CH-2 was given for 7 days on the 8th day animals were operated on for ligation. The MABP and the time of onset of ventricular tachycardia (VT), premature ventricular systole (PVS) were recorded. For induction of hypercholesterolemia, animals were fed with a high cholesterol diet (CD) with CH-1 and CH-2 for 21 days. The antioxidant potential of CH was done using the assay of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). Results: CH treatment significantly decreases the MABP, the onset of VT and PVS. The histology show intact cardiac muscle with minimum necrosis and inflammation. CH treatment shows significant decrease in cholesterol, triglycerides, and glucose while HDL levels are significantly increased. The aortic section of CH-treated animals shows the intact layers of the artery, normal thickness and restoration of antioxidant enzymatic activity. Conclusion: The study shows significant cardio protective effect of CH in experimental animals. |
| first_indexed | 2024-04-11T05:29:20Z |
| format | Article |
| id | doaj.art-7a8b3f35dfe34f1ea3bfdf5be79eda45 |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-04-11T05:29:20Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-7a8b3f35dfe34f1ea3bfdf5be79eda452022-12-23T04:37:32ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762022-10-01134100652Cardio-protective effect of Cocculus hirsutus in experimental hypertension in ratsS.M. Gunjegaonkar0V.R. Khakal1A.A. Joshi2S.L. Nargund3S.D. Shinde4N.S. Khan5ASPM's K. T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, 413 501, Maharashtra, India; Corresponding author. Department of Pharmacology, ASPM's K. T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad- 413 501, Maharashtra, India.Nargund College of Pharmacy 2nd Main Dattatreyanagar, 100FET Ring Road, Banashankari 3rd Stage Bangalore, 560 085, Karnataka, IndiaASPM's K. T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, 413 501, Maharashtra, IndiaNargund College of Pharmacy 2nd Main Dattatreyanagar, 100FET Ring Road, Banashankari 3rd Stage Bangalore, 560 085, Karnataka, IndiaShri. R. D. Bhakt College of Pharmacy, Department of Pharmacology, Jalna, 431203, Maharashtra, IndiaASPM's K. T. Patil College of Pharmacy, Siddharth Nagar, Barshi Road, Osmanabad, 413 501, Maharashtra, IndiaBackground: Ayurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. Objectives: The present study aimed to find the cardio-protective effect of CH in experimental hypertension in rats. Materials and methods: For acute renal hypertension, CH animals were pre-treated with CH-1 (250 mg/kg) and CH-2 (500 mg/kg) p. o. for 14 days. On the 15th day, hypertension was induced by renal occlusion and the mean arterial blood pressure (MABP) was recorded. For CAL pretreatment of CH-1 and CH-2 was given for 7 days on the 8th day animals were operated on for ligation. The MABP and the time of onset of ventricular tachycardia (VT), premature ventricular systole (PVS) were recorded. For induction of hypercholesterolemia, animals were fed with a high cholesterol diet (CD) with CH-1 and CH-2 for 21 days. The antioxidant potential of CH was done using the assay of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). Results: CH treatment significantly decreases the MABP, the onset of VT and PVS. The histology show intact cardiac muscle with minimum necrosis and inflammation. CH treatment shows significant decrease in cholesterol, triglycerides, and glucose while HDL levels are significantly increased. The aortic section of CH-treated animals shows the intact layers of the artery, normal thickness and restoration of antioxidant enzymatic activity. Conclusion: The study shows significant cardio protective effect of CH in experimental animals.http://www.sciencedirect.com/science/article/pii/S0975947622001115Cocculus hirsutusCoronary artery ligationAcute renal hypertensionCardioprotectionAntioxidant activityHypercholesterolemia |
| spellingShingle | S.M. Gunjegaonkar V.R. Khakal A.A. Joshi S.L. Nargund S.D. Shinde N.S. Khan Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats Journal of Ayurveda and Integrative Medicine Cocculus hirsutus Coronary artery ligation Acute renal hypertension Cardioprotection Antioxidant activity Hypercholesterolemia |
| title | Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats |
| title_full | Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats |
| title_fullStr | Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats |
| title_full_unstemmed | Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats |
| title_short | Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats |
| title_sort | cardio protective effect of cocculus hirsutus in experimental hypertension in rats |
| topic | Cocculus hirsutus Coronary artery ligation Acute renal hypertension Cardioprotection Antioxidant activity Hypercholesterolemia |
| url | http://www.sciencedirect.com/science/article/pii/S0975947622001115 |
| work_keys_str_mv | AT smgunjegaonkar cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats AT vrkhakal cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats AT aajoshi cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats AT slnargund cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats AT sdshinde cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats AT nskhan cardioprotectiveeffectofcocculushirsutusinexperimentalhypertensioninrats |