Nutritional Status and Potentially Inappropriate Medications in Elderly
(1) Background: The association between polypharmacy and malnutrition has been investigated in several studies; however, few of these specifically deepened the relationship between potentially inappropriate medication and malnutrition. With a descriptive approach, the primary aim of our study was to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/12/3465 |
| _version_ | 1797485965316456448 |
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| author | Simona Loddo Francesco Salis Samuele Rundeddu Luca Serchisu Maria Monica Peralta Antonella Mandas |
| author_facet | Simona Loddo Francesco Salis Samuele Rundeddu Luca Serchisu Maria Monica Peralta Antonella Mandas |
| author_sort | Simona Loddo |
| collection | DOAJ |
| description | (1) Background: The association between polypharmacy and malnutrition has been investigated in several studies; however, few of these specifically deepened the relationship between potentially inappropriate medication and malnutrition. With a descriptive approach, the primary aim of our study was to evaluate the impact of the nutritional status, assessed with the Mini Nutritional Assessment (MNA), on potentially inappropriate medications (PIM), estimated 10-year survival, and the risk of adverse drug reactions in elderly patients; the secondary aim was to evaluate how the Screening Tool of Older People’s Prescriptions (STOPP), Screening Tool to Alert to Right Treatment (START), and BEERS 2019 criteria identify PIM compared to nutritional status. (2) Methods: In this study, 3091 subjects were enrolled, of whom 2748 (71.7%) were women; the median age was 80 years, with an interquartile range between 75 and 85 years of age. The subjects were assessed at the outpatient service for frail older people of the University Hospital of Cagliari. The study population was evaluated for their: MNA, Charlson Comorbidity Index, 10-year survival estimation, BEERS 2019, STOPP and START criteria, and ADR Risk scores. (3) Results: We divided the study population into three groups: MNA1 (MNA score ≥ 24), MNA2 (23.5–17), and MNA3 (<17): the severity of comorbidities, STOPP and START alerts, and BEERS 2019 criteria were significantly worse in both MNA2 and MNA3 compared to MNA1—with the exception of BEERS “non-anti-infective medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults”. Moreover, the estimated 10-year survival was significantly higher in MNA1 than in MNA2 and MNA3, and also in MNA2 compared to MNA3. Finally, the ADR risk scores were significantly lower in MNA1 than in MNA2 and MNA3. (4) Conclusions: Our study demonstrated the association between nutritional status and PIM checked with the BEERS 2019 criteria, and, for the first time, with the STOPP and START criteria. |
| first_indexed | 2024-03-09T23:27:23Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:27:23Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-7a8c95a7b8374041853f647773d969932023-11-23T17:16:29ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011112346510.3390/jcm11123465Nutritional Status and Potentially Inappropriate Medications in ElderlySimona Loddo0Francesco Salis1Samuele Rundeddu2Luca Serchisu3Maria Monica Peralta4Antonella Mandas5Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, ItalyUniversity Hospital “Azienda Ospedaliero-Universitaria” of Cagliari, SS554 Bivio Sestu, 09042 Monserrato, ItalyUniversity Hospital “Azienda Ospedaliero-Universitaria” of Cagliari, SS554 Bivio Sestu, 09042 Monserrato, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy(1) Background: The association between polypharmacy and malnutrition has been investigated in several studies; however, few of these specifically deepened the relationship between potentially inappropriate medication and malnutrition. With a descriptive approach, the primary aim of our study was to evaluate the impact of the nutritional status, assessed with the Mini Nutritional Assessment (MNA), on potentially inappropriate medications (PIM), estimated 10-year survival, and the risk of adverse drug reactions in elderly patients; the secondary aim was to evaluate how the Screening Tool of Older People’s Prescriptions (STOPP), Screening Tool to Alert to Right Treatment (START), and BEERS 2019 criteria identify PIM compared to nutritional status. (2) Methods: In this study, 3091 subjects were enrolled, of whom 2748 (71.7%) were women; the median age was 80 years, with an interquartile range between 75 and 85 years of age. The subjects were assessed at the outpatient service for frail older people of the University Hospital of Cagliari. The study population was evaluated for their: MNA, Charlson Comorbidity Index, 10-year survival estimation, BEERS 2019, STOPP and START criteria, and ADR Risk scores. (3) Results: We divided the study population into three groups: MNA1 (MNA score ≥ 24), MNA2 (23.5–17), and MNA3 (<17): the severity of comorbidities, STOPP and START alerts, and BEERS 2019 criteria were significantly worse in both MNA2 and MNA3 compared to MNA1—with the exception of BEERS “non-anti-infective medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults”. Moreover, the estimated 10-year survival was significantly higher in MNA1 than in MNA2 and MNA3, and also in MNA2 compared to MNA3. Finally, the ADR risk scores were significantly lower in MNA1 than in MNA2 and MNA3. (4) Conclusions: Our study demonstrated the association between nutritional status and PIM checked with the BEERS 2019 criteria, and, for the first time, with the STOPP and START criteria.https://www.mdpi.com/2077-0383/11/12/3465malnutritionelderlyMini Nutritional Assessmentinappropriate medications |
| spellingShingle | Simona Loddo Francesco Salis Samuele Rundeddu Luca Serchisu Maria Monica Peralta Antonella Mandas Nutritional Status and Potentially Inappropriate Medications in Elderly Journal of Clinical Medicine malnutrition elderly Mini Nutritional Assessment inappropriate medications |
| title | Nutritional Status and Potentially Inappropriate Medications in Elderly |
| title_full | Nutritional Status and Potentially Inappropriate Medications in Elderly |
| title_fullStr | Nutritional Status and Potentially Inappropriate Medications in Elderly |
| title_full_unstemmed | Nutritional Status and Potentially Inappropriate Medications in Elderly |
| title_short | Nutritional Status and Potentially Inappropriate Medications in Elderly |
| title_sort | nutritional status and potentially inappropriate medications in elderly |
| topic | malnutrition elderly Mini Nutritional Assessment inappropriate medications |
| url | https://www.mdpi.com/2077-0383/11/12/3465 |
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