Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies

Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the essential reaction of CO<sub>2</sub> hydration in all living organisms, being actively involved in the regulation of a plethora of patho-/physiological conditions. A series of chromene-based sulfonamides were synthesized and tested as po...

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Bibliographic Details
Main Authors: Andrea Angeli, Victor Kartsev, Anthi Petrou, Boris Lichitsky, Andrey Komogortsev, Mariana Pinteala, Athina Geronikaki, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
carbonic anhydrases
CA inhibitors
3β and 3γCAs
docking
cytotoxicity
Online Access:https://www.mdpi.com/1424-8247/15/3/316

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https://www.mdpi.com/1424-8247/15/3/316

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