Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation
The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.
Bibliographic Details
| Main Authors: |
Xing Chen,
Chunyu Yu,
Xinhua Liu,
Beibei Liu,
Xiaodi Wu,
Jiajing Wu,
Dong Yan,
Lulu Han,
Zifan Tang,
Xinyi Yuan,
Jianqiu Wang,
Yue Wang,
Shumeng Liu,
Lin Shan,
Yongfeng Shang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35334-x
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