Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation
The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35334-x |
| _version_ | 1811203665497686016 |
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| author | Xing Chen Chunyu Yu Xinhua Liu Beibei Liu Xiaodi Wu Jiajing Wu Dong Yan Lulu Han Zifan Tang Xinyi Yuan Jianqiu Wang Yue Wang Shumeng Liu Lin Shan Yongfeng Shang |
| author_facet | Xing Chen Chunyu Yu Xinhua Liu Beibei Liu Xiaodi Wu Jiajing Wu Dong Yan Lulu Han Zifan Tang Xinyi Yuan Jianqiu Wang Yue Wang Shumeng Liu Lin Shan Yongfeng Shang |
| author_sort | Xing Chen |
| collection | DOAJ |
| description | The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism. |
| first_indexed | 2024-04-12T02:59:34Z |
| format | Article |
| id | doaj.art-7a8e6c05e40c437e8343403639e5cac3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T02:59:34Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7a8e6c05e40c437e8343403639e5cac32022-12-22T03:50:42ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35334-xIntracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activationXing Chen0Chunyu Yu1Xinhua Liu2Beibei Liu3Xiaodi Wu4Jiajing Wu5Dong Yan6Lulu Han7Zifan Tang8Xinyi Yuan9Jianqiu Wang10Yue Wang11Shumeng Liu12Lin Shan13Yongfeng Shang14Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical UniversityThe carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.https://doi.org/10.1038/s41467-022-35334-x |
| spellingShingle | Xing Chen Chunyu Yu Xinhua Liu Beibei Liu Xiaodi Wu Jiajing Wu Dong Yan Lulu Han Zifan Tang Xinyi Yuan Jianqiu Wang Yue Wang Shumeng Liu Lin Shan Yongfeng Shang Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation Nature Communications |
| title | Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation |
| title_full | Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation |
| title_fullStr | Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation |
| title_full_unstemmed | Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation |
| title_short | Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation |
| title_sort | intracellular galectin 3 is a lipopolysaccharide sensor that promotes glycolysis through mtorc1 activation |
| url | https://doi.org/10.1038/s41467-022-35334-x |
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